Recruiting

Vaping

Sponsor:

University of Miami

Code:

NCT05454267

Conditions

Vaping

Blood Vessel Injury

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Study Details

Brief summary:

The purpose of this study is to determine how vaping affects blood vessels, in particular if early damage occurs in the lung vessels.

Conditions

Vaping

Blood Vessel Injury

Study ID

NCT05454267

Start date

Sep 12, 2022

Status verified date

May, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Accepted

Inclusion Criteria:

Vapers Group:

1. Current electronic cigarette (EC) Puff Bar users defined as using EC either daily or occasionally in the past 30 days for at least 6 months, and with 5% nicotine concentration pods.
2. Adults aged 18-40 years

Healthy Group:

1. Healthy never smokers, never vapers
2. Adults aged 18-40 years

Exclusion Criteria:

1. Current or past smoking of tobacco cigarette (TC) or other tobacco/nicotine products (e.g., smokeless tobacco, Hookah) or marijuana will be excluded from the study.
2. Subjects with self-reported history of chronic health problems including asthma, chronic obstructive pulmonary disease (COPD), morbid obesity (BMI>40 kg/m2), hypertension or diabetes
3. Pregnant or breastfeeding women

Study Design

Enrollment

90 participants

Anticipated

Interventions and Outcome Measures

Arms

Healthy Volunteer Group

Participants who have never smoked or vaped

High Frequency Vaping Group

Participants who vape >20 days per month.

Low-Frequency Vaping Group

Participants who vape < 20 days per month

Primary outcome measure

  • Airway blood flow reactivity (QAW) [ Time Frame: Up to 1 week ]
  • Pulmonary vascular resistance (PVR) [ Time Frame: Up to 4 weeks ]
  • Flow-mediated vasodilation (FMD) [ Time Frame: Up to 4 weeks ]

Central Contacts and Locations

Central contacts

Adam Wanner, MD

(305)243-2568awanner@med.miami.edu

Michael Campos, MD

3052436388mcampos1@med.miami.edu

Locations

University of Miami Health System

Recruiting

Miami, Florida, United States, 33136

Contacts

Michael Campos, MD

3052436388mcampos1@med.miami.edu

Principal Investigator:

Adam Wanner, MD

More Information

Sponsor

University of Miami

Last update posted

May 15, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Miami on 2026-05-15.