Recruiting
Phase 1
Phase 2

SV2A

Sponsor:

Yale University

Code:

NCT05465538

Conditions

Cannabis Use

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Interventions

[11C]UCB-J PET

Study Details

Brief summary:

The aim of the study is to examine the effect of cannabis use on brain synaptic density among older adults using \[11C\]UCB-J PET imaging.

Conditions

Cannabis Use

Study ID

NCT05465538

Start date

Jul 6, 2022

Status verified date

Feb, 2026

Completion date

Sep 30, 2027

Anticipated

Primary completion date

Dec 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Able to provide informed consent
  • Male or female, aged ≥50 years
  • No history of significant medical or neurological disease
  • BMI ≤ 50
  • If woman of childbearing potential, must agree to use an acceptable method of birth control, as determined by the principal investigator, for the duration of the study and up to one month after completion of PET scans

Exclusion Criteria:

  • Women with a positive pregnancy test or women who are lactating
  • Have had exposure to ionizing radiation that in combination with the study tracer would result in a cumulative exposure that exceeds recommended exposure limits;
  • History of a bleeding disorder or are currently taking anticoagulants
  • Subjects who have donated blood within 8 weeks of the present study

Study Design

Enrollment

24 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Cannabis using older adults

Subjects undergo a single PET scan using \[11C\]UCB-J

other: Healthy controls

Subjects undergo a single PET scan using \[11C\]UCB-J

Interventions

[11C]UCB-J PET

Single PET scan using the radioligand \[11C\]UCB-J

Primary outcome measure

  • Hippocampal synaptic density [ Time Frame: 1 month ]

Central Contacts and Locations

Central contacts

Angerlyk Frytz, MD

203-974-7822angerlyk.frytz@yale.edu

Locations

Conneticut Mental Health Center

Recruiting

New Haven, Connecticut, United States, 06519

Contacts

Angerlyk Frytz, MD

203-974-7822angerlyk.frytz@yale.edu

More Information

Sponsor

Yale University

Last update posted

Feb 27, 2026

Last verified

Feb, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Yale University on 2026-02-27.