Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT05477277

Conditions

End Stage Liver DIsease

Sarcopenia

Sarcopenic Obesity

Cirrhosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

MAsS

Study Details

Brief summary:

Prospective natural history pilot study to explore the link between muscle composition using an MRI-based Muscle Assessment Score (MAsS) and adverse outcomes in liver transplant candidates.

Conditions

End Stage Liver DIsease

Sarcopenia

Sarcopenic Obesity

Cirrhosis

Study ID

NCT05477277

Start date

Nov 2, 2022

Status verified date

Aug, 2026

Completion date

Dec 31, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. All patients with end-stage liver disease undergoing evaluation for liver transplantation
2. Patient clinically indicated for MRI during transplant candidacy evaluation
3. Adult

Exclusion Criteria:

1\. Contra indication to MRI

Study Design

Enrollment

100 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

experimental: Define MAsS cut-point at transplant evaluation to identify those with high risk for adverse outcomes

Interventions

MAsS

Add MAsS to standard of care MRI scan

Primary outcome measure

  • Muscle assessment score (MAsS) [ Time Frame: 1 year ]
  • Adverse outcomes [ Time Frame: 1 year ]
  • Adverse outcomes [ Time Frame: 1 year ]
  • Adverse outcomes [ Time Frame: 1 year ]
  • Adverse outcomes [ Time Frame: 1 year ]
  • MAsS changes while waiting for liver transplant [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Latasha Bunkley

480.342.5756bunkley.latasha@mayo.edu

Locations

Mayo Clinic Arizona

Recruiting

Phoenix, Arizona, United States, 85259

Contacts

Elizabeth Carey, MD

480-342-1094

More Information

Sponsor

Mayo Clinic

Last update posted

Aug 5, 2026

Last verified

Aug, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-08-05.