Recruiting

Observational Study

Sponsor:

Emory University

Code:

NCT05478213

Conditions

Ventricular Tachycardia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Monophasic Action Potential (MAP) Catheter

Study Details

Brief summary:

The purpose of this study is to understand why certain hearts have ventricular arrhythmias and help identify areas of the heart that cause arrhythmias. There is still a significant gap in understanding why ventricular arrhythmias occur. This study will examine the electrical properties of the heart tissue to understand how these arrhythmias occur, and hopefully identify areas that might lead to ventricular arrhythmias. The hope is that studying this might be able to improve outcomes during ventricular tachycardia (VT) ablations.

Conditions

Ventricular Tachycardia

Study ID

NCT05478213

Start date

Oct 25, 2022

Status verified date

Jun, 2026

Completion date

May, 2027

Anticipated

Primary completion date

May, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of ischemic cardiomyopathy
  • Single or dual chamber implantable cardioverter-defibrillator (ICD)

Exclusion Criteria:

  • Non-Ischemic cardiomyopathy
  • Contraindication to catheter ablation
  • Severe peripheral arterial disease or medical condition that prohibit arterial access
  • Ventricular tachycardia (VT) or sudden cardiac arrest (SCA) within 30 days of acute coronary syndrome or within 90 days of coronary revascularization

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Monophasic Action Potential (MAP) Catheter

Participants undergoing ventricular tachycardia ablation per standard of care will also have cellular action potential of the ventricular myocardium assessed with the MAP catheter.

Interventions

Monophasic Action Potential (MAP) Catheter

The EasyMap catheter is a temporary quadripolar catheter for recording monophasic action potentials and for intracardiac pacing. During a standard of care VT ablation, the MAP catheter will be used to study cellular action potential of the ventricular myocardium, which cannot be done on traditional catheters. The catheter is placed on the myocardium (similar to other traditional catheters) and a recording signal is transmitted to the workstation. Using the MAP catheter the will not interrupt or distort any of the standard treatment procedures.

Primary outcome measure

  • Waveform Morphology [ Time Frame: During ablation on Day 1 ]
  • Conduction Velocity [ Time Frame: During ablation on Day 1 ]

Central Contacts and Locations

Central contacts

Neal Bhatia, MD

404-686-7878neal.kumar.bhatia@emory.edu

Locations

Emory University Hospital Midtown

Recruiting

Atlanta, Georgia, United States, 30308

Emory Clinic

Recruiting

Atlanta, Georgia, United States, 30322

Emory University Hospital

Recruiting

Atlanta, Georgia, United States, 30322

More Information

Sponsor

Emory University

Last update posted

Jun 30, 2026

Last verified

Jun, 2026

Keywords

  • Ventricular tachycardia ablation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Emory University on 2026-06-30.