Recruiting

Platelet Rich Plasma

Sponsor:

Stanford University

Code:

NCT05479474

Conditions

Male Infertility

Nonobstructive Azoospermia

Azoospermia

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Platelet rich plasma

Study Details

Brief summary:

Investigate the effect of intratesticular injection of autologous platelet rich plasma (PRP) on sperm retrieval rates and IVF outcomes in infertile men who already underwent a negative sperm retrieval. Currently, there is no alternative treatment after failed TESE. Prior series suggest that intratesticular PRP injections may improve TESE outcomes. We hope to determine whether PRP is an effective treatment for this patient population.

Conditions

Male Infertility

Nonobstructive Azoospermia

Azoospermia

Study ID

NCT05479474

Start date

Jan 18, 2023

Status verified date

Jan, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Male

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Men over the age of 18 diagnosed with NOA and at least one failed TESE, negative mapping or negative biopsy

Exclusion Criteria:

\-

Study Design

Enrollment

10 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Platelet rich plasma treatment arm

After consent in obtained, the patient will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle.

Interventions

Platelet rich plasma

Patients will undergo a blood draw (12 tsp) to prepare the PRP infusion. The use of a centrifuge and an Arteriocyte Magellan kit are necessary for the PRP preparation. After injection of local anesthesia, PRP will be injected into each testicle.

  • On the third month after the testicular PRP procedure, a TESE will be performed
  • If the procedure is successful a new IVF cycle using the sperm procured from the procedure will be done.

Primary outcome measure

  • sperm present [ Time Frame: 3 months after PRP injection ]

Central Contacts and Locations

Central contacts

Satvir Basran

650-723-0948sbasran@stanford.edu

Locations

Stanford Urology Clinic

Recruiting

Stanford, California, United States, 94304

Contacts

Satvir Basran

650-723-0948sbasran@stanford.edu

More Information

Sponsor

Stanford University

Last update posted

Jan 13, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Stanford University on 2026-01-13.