Recruiting

Exercise

Sponsor:

University of Regina

Code:

NCT05496881

Conditions

Multiple Sclerosis, Primary Progressive

Multiple Sclerosis, Relapsing-Remitting

Multiple Sclerosis, Secondary Progressive

Multiple Sclerosis, Chronic Progressive

Multiple Sclerosis

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Exercise Group 1

Exercise Group 2

Exercise Group 3

Study Details

Brief summary:

A growing body of work suggests that regular exercise can support symptom management and improve physical function for people living with multiple sclerosis (MS). Although exercise is known to be beneficial for managing many symptoms related to MS, its effects on the central nervous system, and whether these effects change with different types of exercise, are not well understood. Here, the investigators have designed a clinical trial that compares the effects of distinct exercise protocols on aspects of physical function, physical fitness, and central nervous system function. This research will be the first to compare the effects of different types of exercise on central nervous system changes in people with MS.

Conditions

Multiple Sclerosis, Primary Progressive

Multiple Sclerosis, Relapsing-Remitting

Multiple Sclerosis, Secondary Progressive

Multiple Sclerosis, Chronic Progressive

Multiple Sclerosis

Study ID

NCT05496881

Start date

Jun 15, 2022

Status verified date

Jan, 2024

Completion date

Apr 30, 2025

Anticipated

Primary completion date

Oct 31, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • diagnosis of progressive MS by a neurologist
  • physician clearance for exercise
  • a Patient-Determined Disease Steps (PDSS) score between 3 and 7 (i.e., moderate motor disability)
  • a Timed 25-Foot Walk (T25-FW) test time > 6.0 s.

Exclusion Criteria:

  • a baseline score >24 on the Godin-Shephard Leisure Time Physical Activity Questionnaire (i.e., high physical activity levels)
  • absolute contraindications to TMS (e.g. history of seizure)
  • a history of any neurological conditions other than MS
  • relapse in the past three months (self-reported, neurologist confirmed)
  • psychiatric diagnosis
  • substance abuse

Study Design

Enrollment

69 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Supportive Care

Interventions and Outcome Measures

Arms

experimental: Exercise Group 1

The intervention will focus on mobility and balance.

active comparator: Exercise Group 2

This intervention will focus on physical fitness.

sham comparator: Exercise Group 3

This intervention will focus on flexibility, range of motion, and muscle tone.

Interventions

Exercise Group 1

Prescribed exercises will focus on mobility and balance.

Exercise Group 2

Prescribed exercises will focus on physical fitness.

Exercise Group 3

Prescribed exercises will focus on flexibility, range of motion, and muscle tone.

Primary outcome measure

  • Timed 25-Foot Walk Test [ Time Frame: 6 weeks post intervention ]

Central Contacts and Locations

Central contacts

Cameron Mang, PhD

306-585-4066cameron.mang@uregina.ca

Locations

University of Regina

Recruiting

Regina, Saskatchewan, Canada, S4S5N6

Contacts

Cameron S Mang, PhD

3065854066cameron.mang@uregina.ca

More Information

Sponsor

University of Regina

Last update posted

Feb 15, 2024

Last verified

Jan, 2024

Keywords

  • Progressive Multiple Sclerosis
  • Relapsing-Remitting Multiple Sclerosis
  • Central Nervous System
  • Motor Learning
  • Transcranial Magnetic Stimulation
  • Mobility Limitation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Regina on 2024-02-15.