Recruiting

Trigger Timing

Sponsor:

Fertility Center of Las Vegas

Code:

NCT05498350

Conditions

Infertility, Female

Eligibility Criteria

Sex: Female

Age: 18 - 34

Healthy Volunteers: Accepted

Interventions

Ovulatory trigger timing

Study Details

Brief summary:

This randomized trial will compare the efficacy of two different times of administration of medications for final oocyte maturation, commonly called a "trigger", in cycles of controlled ovarian stimulation (COS) for cycles in which all embryos will be cryopreserved ("freeze-all cycles").

Conditions

Infertility, Female

Study ID

NCT05498350

Start date

Aug 10, 2022

Status verified date

Aug, 2022

Completion date

Nov 30, 2025

Anticipated

Primary completion date

Aug 31, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18 - 34

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Adult female at least 18 years of age and less than 35 years of age intending to undergo ovarian stimulation for a cycle of IVF with all embryos to be frozen that attain the blastocyst stage.
2. Anticipated at least normal ovarian response evidenced by at least 8 antral follicles observed on ultrasound or a serum level of at least 1.5 ng/ml AMH.
3. Ability read and understand English sufficiently to obtain informed consent.
4. Patients with prior IVF cycles are allowed, but no patient can undergo more than one cycle with oocyte collection under this study.

Exclusion Criteria:

1. Any cycle type that would preclude immediate culture to blastocyst stage (e.g. oocyte banking).
2. Any condition that, in the opinion of the physician or principal investigator, would place the patient at undue risk under this protocol or would otherwise make the protocol inappropriate for that subject.

Study Design

Enrollment

150 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Early Trigger

experimental: Delayed trigger

Interventions

Ovulatory trigger timing

Timing of medication to induce final oocyte maturation

Primary outcome measure

  • Good-quality blastocysts [ Time Frame: Within 7 days of oocyte retrieval ]
  • Delayed blastocyst formation [ Time Frame: Within 7 days of oocyte retrieval ]

Central Contacts and Locations

Central contacts

Locations

Fertility center of Las Vegas

Recruiting

Las Vegas, Nevada, United States, 89117

Contacts

More Information

Sponsor

Fertility Center of Las Vegas

Last update posted

Aug 12, 2022

Last verified

Aug, 2022

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Fertility Center of Las Vegas on 2022-08-12.