Observational StudyMeasures of Respiratory Health Registry

Participants with CF

Inclusion Criteria:

-Diagnosis of CF as evidenced by one or more clinical feature consistent with the CF phenotype or positive CF newborn screen AND one or more of the following criteria: i. A documented sweat chloride ≥ 60 mEq/L by quantitative pilocarpine iontophoresis (QPIT).

ii. A documented genotype with two disease-causing mutations in the CFTR gene.

- In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing

Exclusion Criteria:

• Physical findings at the screening that would compromise the safety of the participant or the quality of the data (e.g. respiratory distress or work of breathing)
• Requirement of supplementary oxygen to maintain oxygen saturation above 95%

Participants with other Respiratory Disease

Inclusion criteria:

• Physician-diagnosed lung disease
• Informed consent by participant, parent, or legal guardian
• In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing

Exclusion criteria

• Physical findings at screening that would compromise the safety of the participant or the quality of the research data
• Requirement of supplementary oxygen to maintain oxygen saturation above 95%

Healthy Participants

• Inclusion criteria
• Informed consent by participant, parent, or legal guardian
• In the opinion of the investigator, the participant will likely have the ability to perform the lung function test of interest on the day of testing

Exclusion criteria

• Physical findings at screening that would compromise the safety of the participant or the quality of the research data
• Evidence of lung disease