Recruiting

Airway Resuscitation

Sponsor:

Montefiore Medical Center

Code:

NCT05520762

Conditions

Cardiac Arrest

Respiratory Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

A strategy of first choice supraglottic airway

A strategy of first choice endotracheal intubation

Study Details

Brief summary:

The Hospital Airway Resuscitation Trial (HART) is a cluster-randomized, pragmatic trial of advanced airway management with a strategy of first choice supraglottic airway vs. first choice endotracheal intubation during in-hospital cardiac arrest.

Conditions

Cardiac Arrest

Respiratory Failure

Study ID

NCT05520762

Start date

Feb 10, 2023

Status verified date

Nov, 2025

Completion date

Feb, 2027

Anticipated

Primary completion date

Jan, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adult aged >=18 years
2. Admitted to the hospital for any condition
3. Suffered in-hospital cardiac arrest (loss of pulse and ≥2 minutes of chest compressions)
4. Need for assisted ventilation (defined by initiation of bag-mask-ventilation or other supported ventilation)

Exclusion Criteria:

1. Cardiac arrest in the Operating Room or other area not responded to by Critical Care/Emergency Department (ED) teams.
2. Cardiac arrest in which an invasive airway (i.e. endotracheal tube, tracheostomy tube) is already in place
3. Patients with Do Not Resuscitate or Do Not Intubate orders

Study Design

Enrollment

1060 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: First choice supraglottic airway device, Then First choice endotracheal intubation

A strategy of 'first choice' supraglottic airway during cardiac arrest. Clinicians can deviate to the airway management approach of their choice if deemed to be in the best interest of the patient. As part of a cluster-randomized design, hospitals (4 in the system) will be assigned to one arm for a month and then cross-over to the other arm.

active comparator: First choice endotracheal intubation, Then First choice supraglottic airway

A strategy of 'first choice' endotracheal intubation during cardiac arrest. Clinicians can deviate to the airway management approach of their choice if deemed to be in the best interest of the patient. As part of a cluster-randomized design, hospitals (4 in the system) will be assigned to one arm for a month and then cross-over to the other arm.

Interventions

A strategy of first choice supraglottic airway

See description in Arms section

A strategy of first choice endotracheal intubation

See description in Arms section

Primary outcome measure

  • Alive-and-ventilator free days [ Time Frame: From cardiac arrest until 28-days after cardiac arrest ]

Central Contacts and Locations

Central contacts

Ari Moskowitz, MD

718-920-5440amoskowitz@montefiore.org

Locations

Montefiore Medical Center

Recruiting

New York, New York, United States, 10467

Contacts

Ari Moskowitz, MD

718-920-5440amoskowitz@montefiore.org

Daniel Ceusters

718-920-5440dceuster@montefiore.org

More Information

Sponsor

Montefiore Medical Center

Last update posted

Nov 21, 2025

Last verified

Nov, 2025

Keywords

  • Cardiac Arrest
  • Emergency Airway Management
  • In-hospital Cardiac Arrest
  • Endotracheal Intubation
  • Supraglottic Airway

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Montefiore Medical Center on 2025-11-21.