Recruiting

Blood Pressure

Sponsor:

The University of Texas at Arlington

Code:

NCT05522075

Conditions

Alcohol Drinking

Binge Drinking

Blood Pressure

Alcohol Abstinence

Aging

Eligibility Criteria

Sex: All

Age: 50 - 64

Healthy Volunteers: Accepted

Interventions

Exercise Training

Alcohol Abstinence Intervention

Study Details

Brief summary:

This study has two phases:

Phase 1 is to examine blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers vs. alcohol abstainers/moderate drinkers.

Phase 2 is to examine the effect of 8-week aerobic exercise training on blood pressure, microvascular function, and sympathetic nerve activity in mid-life adult binge drinkers

Conditions

Alcohol Drinking

Binge Drinking

Blood Pressure

Alcohol Abstinence

Aging

Study ID

NCT05522075

Start date

Nov 21, 2022

Status verified date

May, 2026

Completion date

Apr 30, 2027

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 50 - 64

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Men and women (50-64 years of age) who do not drink alcohol, who drink at moderate levels, or who binge drink
  • Female subjects will be postmenopausal (i.e., cessation of menses for ≥1 yr).
  • Subjects who can speak and understand English.

Exclusion Criteria:

  • a history of diabetes, cardiovascular disease, liver, or renal disease
  • current or history of smoking and illicit drug use
  • blood pressure ≥160/100 mm Hg
  • other known traditional cardiovascular disease risks: obesity (BMI≥35 kg/m2), or hyperlipidemia (total cholesterol>230 mg/dl and/or LDL cholesterol>160 mg/dl)
  • active infection (in the past 2 months)
  • a history of seizures, cancer, or inflammatory disease (i.e., gout or rheumatoid)
  • unstable body weight (>5% change during the past 6 months)
  • regular aerobic exercise training (i.e., they engage in 30 min of structured aerobic exercise at least 3 times per week)
  • current use of hormone replacement therapy (i.e., estrogen, progesterone, and testosterone)

Study Design

Enrollment

55 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Exercise Group

Binge drinkers who have been assigned to exercise group will receive baseline assessment, 8-week exercise training plus alcohol abstinence intervention, and post-intervention assessment.

active comparator: Non-exercise Group

Binge drinkers who have been assigned to non-exercise group will receive baseline assessment, 8-week alcohol abstinence intervention, and post-intervention assessment.

no intervention: Alcohol abstainer/moderate drinker group

Alcohol abstainer/moderate drinker will complete baseline assessment only and will not receive any intervention.

Interventions

Exercise Training

Subjects will be asked to perform exercise training (high-intensity interval training) under supervision, 3 times per week for 8 weeks. Each training session will last 40 minutes and will consist of 10-minute warm up at 70% of maximal heart rate (HRmax), four 4-minute intervals at 90% of HRmax with 3-min active recovery at 70% of HRmax and 5-minute cool down at 70% of HRmax.

Alcohol Abstinence Intervention

Subjects will be asked to abstain from alcohol for 8 weeks. Education materials and bi-weekly consultations will be provided.

Primary outcome measure

  • Feasibility of high-intensity interval training [ Time Frame: Through out the study participation (~3 months) ]

Central Contacts and Locations

Central contacts

Chueh-Lung Hwang, PhD

8172729722chuehlung.hwang@uta.edu

Locations

University of Texas at Arlington

Recruiting

Arlington, Texas, United States, 76010

Contacts

Chueh-Lung Hwang, PhD, PT

817-272-9722chuehlung.hwang@uta.edu

More Information

Sponsor

The University of Texas at Arlington

Last update posted

Jun 1, 2026

Last verified

May, 2026

Keywords

  • Exercise training
  • High-intensity interval training
  • Midlife adults
  • Middle-aged
  • Microvascular function
  • Sympathetic nerve activity

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by The University of Texas at Arlington on 2026-06-01.