Recruiting

Cardiac Rehabilitation

Sponsor:

University of Toronto

Code:

NCT05522959

Conditions

Breast Cancer

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Women with breast cancer who are referred to the cardiac rehabilitation program at the Toronto Rehabilitation Institute will be invited to enrol in this observational study. Participants will take part in an established 16-week multimodal cardiac rehabilitation program (HEALTh program) at Toronto Rehabilitation Institute and outcome measures will be assessed before and after program participation to determine the effectiveness of the program in improving cardio metabolic health. Change in VO₂peak will be assessed using Cardiopulmonary Exercise Test (CPET). Traditional cardiac risk factors, lifestyle behaviours, exercise adherence, health-related quality of life, and fatigue will also be assessed.

Conditions

Breast Cancer

Study ID

NCT05522959

Start date

Mar 14, 2022

Status verified date

Sep, 2025

Completion date

Dec, 2026

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • History of early-stage breast cancer (I-III)
  • Currently receiving or have completed adjuvant therapy (i.e. chemotherapy, surgery, radiation, targeted therapies)
  • Able to communicate in English

Exclusion Criteria:

  • Pregnancy
  • Metastatic disease (Stage IV)
  • Unable or unwilling to complete cardiopulmonary exercise test

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Cardiopulmonary Fitness [ Time Frame: post-intervention (16 weeks) ]

Central Contacts and Locations

Central contacts

Amy A Kirkham, PhD

(416) 946-4069‬‬amy.kirkham@utoronto.ca

Locations

Toronto Rehabilitation Institute

Recruiting

Toronto, Ontario, Canada

Contacts

Paul Oh, MD

Paul.Oh@uhn.ca

More Information

Sponsor

University of Toronto

Last update posted

Oct 1, 2025

Last verified

Sep, 2025

Keywords

  • Cardiac Rehabilitation
  • Cardio-oncology
  • Cardiometabolic Health
  • Cardiovascular Disease Risk

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Toronto on 2025-10-01.