Recruiting

Perceptual Learning

Sponsor:

Nova Southeastern University

Code:

NCT05522972

Conditions

Amblyopia

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Interventions

Video Game Vision Training

Perceptual Learning

Occlusion Therapy

Study Details

Brief summary:

Amblyopia, a developmental abnormality that impairs spatial vision, is a major cause of vision loss, resulting in reduced visual acuity and reduced sensitivity to contrast. This study uses psychophysical measures to study neural plasticity in both adults and children with amblyopia.

Conditions

Amblyopia

Study ID

NCT05522972

Start date

Sep 13, 2022

Status verified date

Dec, 2025

Completion date

Aug 31, 2029

Anticipated

Primary completion date

Aug 31, 2029

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • adults and children with normal vision or amblyopia
  • amblyopia: interocular VA difference of 0.1 logMAR or more

Exclusion Criteria:

  • any ocular pathological conditions, nystagmus

Study Design

Enrollment

180 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Video Games

Participants will be required to play video games for a period of time: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months

experimental: Perceptual learning

Participants will be required to practice a visual discrimination task (e.g. visual acuity, position acuity, contrast sensitivity, \& stereoacuity) for a period of time: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months

active comparator: Occlusion therapy

Participants will be required to cover the dominant eye during the day in order to push the brain to use the fellow amblyopic eye: 1-2 hrs per session, 4-5 sessions/week for \~1-6 months

Interventions

Video Game Vision Training

A new approach for improving amblyopic vision using video games

Perceptual Learning

A new approach for improving amblyopic vision with perceptual learning

Occlusion Therapy

Conventional treatment for amblyopia

Primary outcome measure

  • Change in visual acuity before and after the intervention [ Time Frame: 9 months ]
  • Change in stereoacuity before and after the intervention [ Time Frame: 9 months ]

Central Contacts and Locations

Central contacts

Roger W Li, OD, PhD

954-262-1436wli@nova.edu

Locations

Nova Southeastern University College of Optometry

Recruiting

Fort Lauderdale, Florida, United States, 33328

Contacts

Roger Li, OD, PhD

954-262-1436wli@nova.edu

More Information

Sponsor

Nova Southeastern University

Last update posted

Dec 16, 2025

Last verified

Dec, 2025

Keywords

  • perceptual learning
  • video games
  • visual plasticity
  • amblyopia treatment
  • pathophysiology of amblyopia
  • vision training
  • stereoacuity
  • strabismus

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Nova Southeastern University on 2025-12-16.