Recruiting

Cerebral Aneurysms

Sponsor:

University Hospital, Geneva

Code:

NCT05526352

Conditions

Intracranial Aneurysm

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The primary aim of the SwissNeuroFoundation AneurysmDataBase Project is to implement information technology based tools to create and use a holistic reference database specific to intracranial aneurysms (IA).

The SwissNeuroFoundation AneurysmDataBase are concerned with generating the data with which to populate this database.

The purpose for populating the database are to:

  • Screen for and evaluate markers of risk for intracranial aneurysm formation and aneurysm rupture. Are considered as markers the following: genetics factors, microbiota, environmental factors, congenital factors (ie: cerebrovascular anatomical variants), transcriptomics signature, proteomics signature,shape characteristics, haemodynamics characteristics.
  • Screen for and evaluate prognostic factors of outcome regarding different management strategies including watchful observation, microsurgical treatment, endovascular treatment or any combination thereof.
  • Implement and evaluate patient-specific management protocols integrating all available information.
  • Evaluate the impact of the database and use of tools to improve care, reduce costs, support knowledge discovery and promote new industrial developments.

Conditions

Intracranial Aneurysm

Study ID

NCT05526352

Start date

Jun 1, 2015

Status verified date

Jan, 2026

Completion date

Mar 1, 2040

Anticipated

Primary completion date

Mar 1, 2040

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • able to provide consent or, in the event that a patient is incapable of providing consent, that a person is legally authorized to do so on behalf of the patient according to legal and ethical requirements of the country where the clinical centre is located.

Patients:

  • must have an angiographically proven intracranial aneurysm (MRA< CTA< DSA accepted).The determination of SAH requires the presence of a subarachnoid haemorrhage be verified on CT or by lumbar puncture.

MRA: Magnetic Resonance Angiography CTA: Computed Tomography Angiography DSA: Digital Subtracted Angiography

Exclusion Criteria:

  • failure of a candidate to contribute clinical data,
  • refusal to provide informed consent.

Study Design

Enrollment

20000 participants

Anticipated

Interventions and Outcome Measures

Arms

IA Patients

Patients with one or more identified intracranial aneurysm, none of which are believed to have ruptured.

IA + SAH Patients

Patients with one or more identified intracranial aneurysm, at least one of which has been radiologically or surgically determined to have ruptured.

Familiy members

Individuals selected on review of a patient's family tree and contacted by said patient, who agree to be approached for recruitment. In affected families each member will be identified as: proband, affected, unaffected, unknown, or not genetically linked.

Healthy Volunteers

Individuals, accompanying or contacted by a patient, or responding to open advertisement, or randomly selected in a defined population who agree to be approached for recruitment.

Primary outcome measure

  • Disease model validation [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Sven Hirsch, Dr

+41 58 934 54 44hirc@zhaw.ch

Philippe Bijlenga, PD MD PhD

+41 22 372 34 26philippe.bijlenga@hcuge.ch

Locations

University of California

Recruiting

San Francisco, California, United States

University of Cincinnati College of Medicine

Recruiting

Cincinnati, Ohio, United States

University of Virginia

Recruiting

Virginia Beach, Virginia, United States

Montreal Neurological Institute and Hospital, McGill University

Recruiting

Montreal, Canada

More Information

Sponsor

University Hospital, Geneva

Last update posted

Jan 16, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Hospital, Geneva on 2026-01-16.