Recruiting

Telo Genomics

Sponsor:

Sir Mortimer B. Davis - Jewish General Hospital

Code:

NCT05530096

Conditions

Multiple Myeloma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Standard of care

Study Details

Brief summary:

The purpose :

Detect and profile Multiple myeloma Measurable Residual Disease(MRD) prognostics for monitoring post-transplant Multiple Myeloma (MM) Patients receiving maintenance therapy.

Conditions

Multiple Myeloma

Study ID

NCT05530096

Start date

May 1, 2024

Status verified date

Mar, 2025

Completion date

Sep, 2028

Anticipated

Primary completion date

Sep, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Confirmed MM diagnosis
  • Transplant eligible patients in a first remission
  • Known MRD level detected by ClonoSeq (other IMWG recognized methodologies can be also employed)
  • Availability of deidentified patient's demographic and clinical follow up data
  • Receiving standard of care treatment
  • Able to provide informed consent

Exclusion Criteria:

  • Failure to meet inclusion criteria

Study Design

Enrollment

70 participants

Anticipated

Interventions and Outcome Measures

Arms

MRD level group

Participants will be defined as diagnosed with multiple myeloma

Interventions

Standard of care

Participants will not receive any intervention in this study. Participants will receive standard of care therapy

Primary outcome measure

  • To validate the sensitivity of Telo Genomics assay (measurement tool) to detect MRD (measurement expressed in the number of plasma cells per 100000 cells) and establish the clinical utility of TELO - DMRD for MRD enumeration [ Time Frame: Approximately 5 years ]
  • To assess the utility of TeloView® technology genomic profiling (measurement tool) to stratify post-transplant MM patients into relapse risk groups (dichotomous measure of high or low) by analyzing the residual MRD plasma cells [ Time Frame: Approximately 5 years ]

Central Contacts and Locations

Central contacts

Rayan Kaedbey, MD FRCPC

514-340-8222rayan.kaedbey.med@ssss.gouv.qc.ca

Locations

Jewish General Hospital

Recruiting

Montreal, Quebec, Canada, H3T 1E2

Contacts

Rayan Kaedbey, MD

514 340 8222rayan.kaedbey@mcgill.ca

More Information

Sponsor

Sir Mortimer B. Davis - Jewish General Hospital

Last update posted

Apr 3, 2025

Last verified

Mar, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Sir Mortimer B. Davis - Jewish General Hospital on 2025-04-03.