Recruiting

Acupuncture & Hypertension

Sponsor:

UCLA

Code:

NCT05530512

Conditions

Mild to Moderate Hypertension

Eligibility Criteria

Sex: All

Age: 45 - 70+

Healthy Volunteers: Not accepted

Interventions

electroacupuncture

Study Details

Brief summary:

Acupuncture therapy will be provided to reduce blood pressure in hypertensive patients. The mild to moderate hypertensive patients will be either on or off hypertensive medications. The course last for 8 weeks and the frequency is once a week.

Conditions

Mild to Moderate Hypertension

Study ID

NCT05530512

Start date

Jan 1, 2023

Status verified date

Jul, 2025

Completion date

Mar 31, 2027

Anticipated

Primary completion date

Mar 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 45 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Subjects from 45 to 75 years of age
2. Clinically diagnosed with mild to moderate hypertension and ON or OFF medication (Office SBP > 140 mmHg and < 160 mmHg Or ABPM average SBP > 130 mmHg and < 145 mmHg), and
3. No significant ECG change reflecting ischemia (i.e. ST elevation or depression) at rest will be recruited to participate in this study.

Exclusion Criteria:

1. Subjects will be excluded if pregnant or nursing.
2. Subjects will be excluded if they have coronary disease (by history or on ECG screening), conduction abnormalities on ECG consistent with left bundle branch block, cardiac arrhythmias associated with low blood pressure (<90 mmHg), peripheral vascular disease, orthopedic disease, diabetic neuropathy or severe hypertension (BP >170 mmHg systolic or >110 mmHg diastolic), or any other physical or psychological illness.
3. Those with known sensitivity to any topical preparations or strong reactions to medical dressings and skin tapes also will be excluded.
4. Inability our or unwillingness of individual to give written informed consent.

Study Design

Enrollment

72 participants

Anticipated

Allocation

Randomized

Intervention Model

Factorial

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Anti-inflammatory EA (AI-EA)

Anti-inflammatory electroacupuncture therapy

experimental: Sympathoinhibitory EA (SI-EA)

sympatho-inhibitory electroacupuncture therapy

experimental: Combined EA (cEA)

combination of SI-EA and AI-EA

experimental: Control EA (Sham-EA)

Sham electroacupuncture

Interventions

electroacupuncture

acupuncture needling and stimulation are applied for 30 min

Primary outcome measure

  • Changes in sympathetic and parasympathetic nervous systems [ Time Frame: through study completion, an average of 4.5 years ]

Central Contacts and Locations

Central contacts

Locations

Susan Samueli Integrative Health Institute

Recruiting

Irvine, California, United States, 92697

Contacts

Mitchell Beasley, MD, PhD, MPH

949-824-7000beasleym@uci.edu

Principal Investigator:

Shaista Malik, MD, PhD, MPH

University of California, Irvine, Health Sciences Medical Center

Recruiting

Orange, California, United States, 92868

Contacts

Herlinda Bergman, M.Sc.

714-456-7090

More Information

Sponsor

University of California, Irvine

Last update posted

Jul 20, 2025

Last verified

Jul, 2025

Keywords

  • hypertension, electroacupuncture

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Irvine on 2025-07-20.