Recruiting

Physical Activity

Sponsor:

University of British Columbia

Code:

NCT05553223

Conditions

Chronic Obstructive Pulmonary Disease

Endothelial Dysfunction

Vascular Stiffness

Hypertension

Cardiovascular Diseases

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Microdoses of activity

Study Details

Brief summary:

Chronic obstructive pulmonary disease (COPD) is a disease of the lungs that makes it hard for people to breath. Those with COPD spend considerably more time sitting and lying and less time performing physical activity than healthy individuals. Those who are the most sedentary have a greater risk of heart and blood vessel disease, which may lead to an early death. This project will investigate the effect of sitting still for 3 hours on blood vessel health in individuals with COPD. It will also investigate whether breaking up the amount of time patients sit with regular short bouts of walking (5 minutes each hour) at a comfortable pace chosen by the patient can have a positive effect on maintaining the health of their blood vessels. It is hypothesized that blood vessel health will be worse after 3 hours of sitting compared to when the sitting is broken up by short bouts of walking.

Conditions

Chronic Obstructive Pulmonary Disease

Endothelial Dysfunction

Vascular Stiffness

Hypertension

Cardiovascular Diseases

Study ID

NCT05553223

Start date

Oct 12, 2022

Status verified date

Apr, 2025

Completion date

Sep 1, 2026

Anticipated

Primary completion date

Sep 1, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Non-smoking (>6 months) patients with stable moderate-to-severe COPD (post bronchodilator forced expired volume in 1 sec/forced vital capacity<0.7 and <lower limit of normal, 30%<Forced Expired Volume in 1 sec<80% predicted and exacerbation free for >6 weeks) will be recruited for the study.

Exclusion Criteria:

1. performing structured exercise training (or pulmonary rehabilitation)
2. have a history of deep vein thrombosis
3. are on anticoagulant medication
4. have advanced cardiac or cerebrovascular disease (i.e. heart failure, previous stroke or myocardial infarction)
5. have diabetes
6. have musculoskeletal contraindications that limit their ability to perform physical activity
7. vascular ultrasound measurements cannot be obtained.

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Prevention

Interventions and Outcome Measures

Arms

experimental: Microdoses of Activity

5-min bouts of walking will break up 3 hours of sitting at minutes 30, 90 and 150.

no intervention: Control

Prolonged sitting (3 hours)

Interventions

Microdoses of activity

Short bouts of low-intensity exercise (walking) will be used to break up prolonged sitting.

Primary outcome measure

  • Change in superficial femoral artery endothelial function [ Time Frame: Within 3 hours of sitting (Day1) or within 3 hours of micro-doses of physical activity (Day 2). Days performed in a randomized order. ]

Central Contacts and Locations

Central contacts

Neil Eves, PhD

250-807-9676neil.eves@ubc.ca

Locations

University of British Columbia

Recruiting

Kelowna, British Columbia, Canada, V1V2L2

Contacts

Neil Eves, PhD

250-807-9676neil.eves@ubc.ca

More Information

Sponsor

University of British Columbia

Last update posted

Apr 4, 2025

Last verified

Apr, 2025

Keywords

  • Microdoses of Physical Activity
  • Flow Mediated Dilation
  • Reactive Hyperemia

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of British Columbia on 2025-04-04.