Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT05556395

Conditions

Ischemic Stroke

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

The goal of this study is to gain a better understanding of why some individuals who have suffered a stroke experience post-stroke cognitive decline. Specifically this study is testing whether global disruption of the blood-brain barrier detected at the time of the stroke is informative about the risk of post-stroke cognitive decline over the next 3 years.

Conditions

Ischemic Stroke

Study ID

NCT05556395

Start date

Apr 1, 2022

Status verified date

Sep, 2026

Completion date

Apr 1, 2027

Anticipated

Primary completion date

Apr 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Acute ischemic stroke demonstrated on an MRI scan that includes perfusion imaging with an exogenous contrast agent

Exclusion Criteria:

  • Inability to perform telephone-based cognitive assessments

Study Design

Enrollment

150 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Change in Cognition (Cognitive Decline) [ Time Frame: Assessments occur every 6 months for 3 years ]

Central Contacts and Locations

Central contacts

Diane Echavarria

410 502 5355dechava1@jhu.edu

Locations

Johns Hopkins Hospital

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Diane Echavarria

410-502-5355dechava1@jhu.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Sep 4, 2026

Last verified

Sep, 2026

Keywords

  • blood-brain barrier
  • post-stroke cognitive impairment and dementia
  • vascular cognitive impairment and dementia
  • Alzheimer's disease and related dementias
  • stroke

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-09-04.