Recruiting

Brain Stimulation

Sponsor:

Colorado State University

Code:

NCT05556655

Conditions

Cognitive Function

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Interventions

Transcranial Magnetic Stimulation

Study Details

Brief summary:

The purpose of this study is to determine optimal task design parameters for the measurement of transcranial magnetic stimulation (TMS) effects on cognition.

Conditions

Cognitive Function

Study ID

NCT05556655

Start date

Apr 20, 2023

Status verified date

Apr, 2026

Completion date

Jan 1, 2028

Anticipated

Primary completion date

Jan 1, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 65

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Right-handed
  • Fluent in English

Exclusion Criteria:

  • History of seizures or epilepsy
  • Family history of epilepsy
  • Significant medical or neurological diagnoses
  • History of common headache or migraine
  • History of common or recent syncope
  • History of moderate/severe, multiple mild, or past 12 months head injury
  • History of psychiatric, psychological, or neurodevelopmental disorder
  • History of alcohol or recreational drug abuse or dependence
  • Current visual or hearing difficulties that interfere with cognitive testing
  • History of cochlear implants
  • Current pregnancy
  • History of metal in the head or neck (except braces and fillings)
  • Current non-removable piercings in the neck or head
  • History of implanted neurostimulator
  • History of cardiac pacemaker or intracardiac lines
  • History of medication infusion device
  • Current use of medications that increase the excitability of the brain
  • History of problems with TMS or MRI procedures
  • History of EEG for suspected epilepsy
  • Alcohol or recreational drug use in the 48 hours prior to TMS
  • Inadequate sleep in the 48 hours prior to TMS
  • Headache or feeling faint in the 24 hours prior to TMS.

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

experimental: Active TMS

Repetitive TMS for the brain

placebo comparator: Sham TMS

Scalp stimulation that does not affect the brain.

Interventions

Transcranial Magnetic Stimulation

Transcranial Magnetic Stimulation (TMS) is a noninvasive method for stimulating neurons (axons not cell bodies) in the brain.

Primary outcome measure

  • Sternberg Memory Task (Accuracy) [ Time Frame: Single study appointment. 1 hour. There will be no follow up. ]
  • Sternberg Memory Task (Reaction Time) [ Time Frame: Single study appointment. 1 hour. There will be no follow up. ]

Central Contacts and Locations

Central contacts

Michael Thomas, PhD

(970) 491-6820Michael.L.Thomas@colostate.edu

Locations

Colorado State University Department of Psychology

Recruiting

Fort Collins, Colorado, United States, 80523

Contacts

Michael L Thomas, PhD

970-491-6820michael.l.thomas@colostate.edu

More Information

Sponsor

Colorado State University

Last update posted

Apr 8, 2026

Last verified

Apr, 2026

Keywords

  • Transcranial Magnetic Stimulation
  • TMS

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-24. This information was provided to ClinicalTrials.gov by Colorado State University on 2026-04-08. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.