Recruiting

Deep Brain Stimulation

Sponsor:

University of Minnesota

Code:

NCT05557864

Conditions

Parkinson's Disease

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Interventions

Deep Brain Stimulation

Study Details

Brief summary:

This protocol will characterize the effects of deep brain stimulation (DBS) location (both adverse and beneficial) on motor signs in people with Parkinson's disease (PD). This information can be used to inform future DBS protocols to tailor stimulation to the specific needs of a patient. If targeted dorsal GP stimulation is shown to significantly improve motor features that are typically resistant to dopamine replacement therapy, these experiments will likely have major impact on clinical practice by providing a potential strategy to these medically intractable symptoms.

Conditions

Parkinson's Disease

Study ID

NCT05557864

Start date

Aug 25, 2016

Status verified date

Jan, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • diagnosis of idiopathic PD
  • have undergone neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)
  • Existing 7T brain imagery

Exclusion Criteria:

  • history of musculoskeletal disorders that significantly affect movement of the upper or lower limbs
  • other significant neurological disorder
  • history of dementia or cognitive impairment as found with UBACC (or MacCAT-CR)
  • post-operative complications or adverse effects

Study Design

Enrollment

24 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Parkinson's disease with DBS

Participants will have a diagnosis of idiopathic PD and have undergone/will undergo neurosurgery to implant deep brain stimulators in the globus pallidus (GP DBS) or subthalamic nucleus (STN)

Interventions

Deep Brain Stimulation

Pallidal Deep Brain Stimulation

Primary outcome measure

  • Changes in the combined elastic, viscous and inertial resistance across conditions will be assessed by integrating the resistive torque [ Time Frame: 3 weeks ]

Central Contacts and Locations

Central contacts

Colum MacKinnon, PhD

cmackinn@umn.edu

Locations

University Of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55455

Contacts

Colum MacKinnon, PhD

cmackinn@umn.edu

More Information

Sponsor

University of Minnesota

Last update posted

Jan 26, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-01-26.