Recruiting

Exercise Training

Sponsor:

University of Colorado, Denver

Code:

NCT05566483

Conditions

Post-acute Sequelae of SARS-CoV-2 Infection

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Exercise

Study Details

Brief summary:

The primary objectives of this study are to determine whether exercise training is an effective strategy for treatment of Long COVID and characterize the cardiorespiratory and autonomic physiology in these patients to precisely characterize mechanisms contributing to this syndrome.

Conditions

Post-acute Sequelae of SARS-CoV-2 Infection

Study ID

NCT05566483

Start date

Mar 1, 2023

Status verified date

Nov, 2025

Completion date

Oct 31, 2027

Anticipated

Primary completion date

Oct 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Adults ≥18 years with documented history of COVID-19 infection and symptoms consistent with Long COVID lasting >12 weeks after diagnosis.

Exclusion Criteria:

  • History of cardiovascular/pulmonary disease prior to infection
  • COVID-related myocardial injury such as evidence of myocarditis
  • Deep vein thrombosis/pulmonary embolism following COVID-19 infection
  • Exercise intolerance resulting from conditions that are not related to cardiorespiratory or autonomic factors (e.g. osteoarthritis or other musculoskeletal diseases);
  • Dependency of supplemental oxygen following COVID infection due to cardiovascular and/or pulmonary complications following acute COVID infection

Study Design

Enrollment

30 participants

Anticipated

Allocation

Randomized

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Exercise

no intervention: Control

Interventions

Exercise

exercise protocol

Primary outcome measure

  • Characterizing the impact of exercise training (cardiac rehabilitation) on functional capacity among patients with Long COVID [ Time Frame: 12 weeks ]
  • Characterizing the impact of exercise training (cardiac rehabilitation) on HRqOL among patients with Long COVID [ Time Frame: 12 weeks ]

Central Contacts and Locations

Central contacts

William K Cornwell, III, MD

303-724-2085william.cornwell@cuanschutz.edu

Locations

University of Colorado Hospital

Recruiting

Aurora, Colorado, United States, 80045

More Information

Sponsor

University of Colorado, Denver

Last update posted

Dec 4, 2025

Last verified

Nov, 2025

Keywords

  • Cardiopulmonary Rehabilitation
  • Long COVID

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Colorado, Denver on 2025-12-04.