Recruiting

Cannabis

Sponsor:

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Code:

NCT05581368

Conditions

Cardiovascular Diseases

Inflammation

Atherosclerosis

Eligibility Criteria

Sex: All

Age: 19 - 70+

Healthy Volunteers: Accepted

Interventions

Chronic Cannabis use

Study Details

Brief summary:

Cannabis is commonly used globally. It is associated with psychiatric problems, but the effects on the cardiovascular system are unclear. In this project, the investigators plan to study the effects of cannabis on the cardiovascular system. This will be done by using a non-invasive test to measure blood vessel function and by using blood samples to measure inflammation. As a control for this project, the investigators would like to test the blood vessel function and inflammation levels of participants who do not use cannabis. This study will provide important information on the long term cardiovascular effects of cannabis.

Conditions

Cardiovascular Diseases

Inflammation

Atherosclerosis

Study ID

NCT05581368

Start date

Dec 1, 2023

Status verified date

Jun, 2025

Completion date

Dec 30, 2025

Anticipated

Primary completion date

Jun 30, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 19 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • age: 19 to 80
  • males and females
  • all ethnicities
  • cannabis use at least 3-4 times per week or more in the past 6 months (50 volunteers, experimental group)
  • patients who do not use cannabis (50 volunteers, control group)
  • no history of cardiovascular disease

Exclusion Criteria:

  • that ingest cannabis containing cannabidiol (CBD)
  • that are unable to provide a receipt for the cannabis product(s) they ingest
  • that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Chronic Cannabis Cohort

For investigations on the effects of cannabis on the cardiovascular system, the investigators would like to recruit 50 participants with the following inclusion criteria:

  • age: 19 to 80
  • males and females
  • all ethnicities
  • cannabis use at least 3-4 times per week or more in the past 6 months (50 volunteers, experimental group)
  • no history of cardiovascular disease

For investigations on the effects of cannabis on the cardiovascular system, the investigators will exclude cannabis users:

  • that ingest cannabis containing cannabidiol (CBD)
  • that are unable to provide a receipt for the cannabis product(s) they ingest
  • that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.

Control Cohort

For investigations on the effects of cannabis on the cardiovascular system, the investigators would like to recruit 50 participants with the following inclusion criteria:

  • age: 19 to 80
  • males and females
  • all ethnicities
  • patients who do not use cannabis
  • no history of cardiovascular disease

For investigations on the effects of cannabis on the cardiovascular system, the investigators will exclude participants:

  • that ingest cannabis
  • that are unwilling to stop consuming soy products and/or genistein 48 hours prior to appointments.

Interventions

Chronic Cannabis use

The investigators will test levels of inflammation and vascular dysfunction in participants who chronically use cannabis.

Primary outcome measure

  • Inflammation [ Time Frame: Baseline measurement. ]
  • Endothelial function [ Time Frame: Baseline measurement. ]

Central Contacts and Locations

Central contacts

Mark Chandy, MD, PhD

5196612111mark.chandy@lhsc.on.ca

Kerry-Ann Nakreiko, PhD

5196612111Kerry-Ann.Nakrieko@lhsc.on.ca

Locations

London Regional Health Science Centre

Recruiting

London, Ontario, Canada, N6A 5A5

More Information

Sponsor

London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

Last update posted

Jun 15, 2025

Last verified

Jun, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's on 2025-06-15.