Recruiting

Sensory Screening

Sponsor:

Washington University School of Medicine

Code:

NCT05582551

Conditions

Childhood Cancer

Eligibility Criteria

Sex: All

Age: 7 - 17

Healthy Volunteers: Not accepted

Interventions

Highlighting Patients at Risk for Sensory Screening (HPARSS)

Study Details

Brief summary:

The overall goal of this study is to attempt to overcome the organizational barriers that impede prompt screening for at-risk sensory deficits in childhood cancer survivors (CCS). Using a cross sectional design study, collaborators in the Informatics Research branch of the Institute of Informatics at the Washington University School of Medicine will identify CCS at risk for sensory deficits based upon their therapy exposure to generate the highlighting patients at risk for sensory screening (HPARSS) document. The investigators will utilize the HPARSS that will link therapy related risks for sensory deficits to specific screening procedures prompting the primary oncology provider to implement screening, diagnostic testing, and therapy.

Conditions

Childhood Cancer

Study ID

NCT05582551

Start date

Aug 2, 2023

Status verified date

Jun, 2026

Completion date

May 31, 2027

Anticipated

Primary completion date

May 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 7 - 17

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients with a diagnosis of pediatric cancer (diagnosis at <18 years of age)
  • Treatment including chemotherapy and/or radiation therapy
  • Completion of all cancer therapy for at least 6 months and less than 2 years
  • Followed in the Division of Pediatric Hematology/Oncology Program at the Washington University School of Medicine
  • Current age between 7 and 17 years of age (age where all of the screening tests are both valid and have been successfully performed by our group)
  • English speaking

Exclusion Criteria:

  • Undergoing active cancer treatment
  • Patient under the care of the Late Effects Program at St. Louis Children's Hospital
  • Received previous diagnostic testing or rehabilitative therapy for a secondary deficit eligible for screening.
  • Parents and/or patient illiteracy
  • No contact with treatment team in the past two years
  • In foster care or without a legal guardian

Study Design

Enrollment

146 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Patients: Highlighting Patients at Risk for Sensory Screening (HPARSS)

  • The primary oncology team will utilize the HPARSS to identify patients who are at risk for sensory deficits based on prior treatment. The HPARSS will constitute a file of that will contain eligible patients based upon their past treatment and their corresponding risk for a particular sensory deficit based upon that treatment. The patient and parent/guardian will be approached to participate in the study.
  • Sensory deficit screening will be completed in the clinic and any screening results that indicate the need for referral for diagnostic testing or therapy will be scheduled by the primary treatment team staff.

no intervention: Providers: Highlighting Patients at Risk for Sensory Screening (HPARSS)

-Providers will complete a survey regarding their views of the HPARSS. The Acceptability of Intervention Measure has 4 questions and the Feasibility of Intervention Measure has 4 questions.

Interventions

Highlighting Patients at Risk for Sensory Screening (HPARSS)

Collaborators in the Informatics Research branch of the Institute of Informatics at the Washington University School of Medicine will identify CCS at risk for sensory deficits based upon their therapy exposure to generate the HPARSS document.

Primary outcome measure

  • Percentage of patients with at risk for sensory deficits identified by HPARSS [ Time Frame: Through completion of enrollment for all patients (estimated to be 9 months) ]
  • Percentage of at risk patients who fail the assigned screening test [ Time Frame: Through completion of enrollment for all patients (estimated to be 9 months) ]
  • Percentage of patients in need of referral for screen test results who participate in formal diagnostic testing and/or treatment [ Time Frame: Through 1 year after the completion of screening test for all participants (estimated to be 1 year and 9 months) ]

Central Contacts and Locations

Central contacts

Robert J Hayashi, M.D.

314-454-6018hayashi_r@wustl.edu

Locations

St. Louis Children's Hospital - Washington University School of Medicine

Recruiting

St Louis, Missouri, United States, 63110

Contacts

Robert J Hayashi, M.D.

314-454-6018hayashi_r@wustl.edu

Principal Investigator:

Robert J Hayashi, M.D.

More Information

Sponsor

Washington University School of Medicine

Last update posted

Jun 15, 2026

Last verified

Jun, 2026

Keywords

  • childhood cancer survivors
  • electronic medical record
  • sensory deficit screening
  • hearing loss
  • peripheral neuropathy
  • vestibular
  • vision

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Washington University School of Medicine on 2026-06-15.