Recruiting

SBRT vs. CRT

Sponsor:

University Health Network, Toronto

Code:

NCT05589701

Conditions

Spinal Metastases

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Interventions

Radiotherapy

Study Details

Brief summary:

This is a single institutional registry-based, prospective, observational study to describe radiation oncologists' decision making during evaluation of patients and to compare real-world outcomes of SBRT vs CRT.

A registry-based trial involves observing the effect of something without manipulating it.

Conditions

Spinal Metastases

Study ID

NCT05589701

Start date

Dec 12, 2022

Status verified date

Mar, 2026

Completion date

Dec, 2027

Anticipated

Primary completion date

Dec, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 70+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Adults 18 years of age or older.
  • Patients seen at the Princess Margaret Cancer Centre with painful spinal metastases amenable to radiation treatment.
  • Confirmation of diagnosis: a) Known/documented prior histological cancer diagnosis
  • Able to provide written consent
  • ECOG performance status 0-3

Exclusion Criteria:

  • Prior radiotherapy, with fields overlapping, resulting in excessive doses to organs at risk
  • Lymphoma, myeloma or germ cell malignancies

Study Design

Enrollment

100 participants

Anticipated

Interventions and Outcome Measures

Arms

Stereotactic Radiotherapy (SBRT)

Standard of care stereotactic radiotherapy.

Conventional Radiotherapy (CRT)

Standard of care conventional radiotherapy.

Interventions

Radiotherapy

Standard of care radiotherapy administered as per institutional guidelines.

Primary outcome measure

  • Describe physician decision-making when making a recommendation for SBRT vs CRT in spine metastasis patients requiring radiation. [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

David Shultz, MD

416-946-4501david.shultz@rmp.uhn.ca

Locations

University Health Network

Recruiting

Toronto, Ontario, Canada, M5G 1X6

Contacts

David Shultz, MD.

416-946-4501david.shultz@rmp.uhn.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-03-05.