Recruiting

Observational Study

Sponsor:

UCLA

Code:

NCT05591937

Conditions

Depression

Anxiety

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Not accepted

Interventions

Self-Guided Online Prevention

Coach-Guided Online Cognitive Behavioral Therapy

Clinician-Delivered Psychological and Psychiatric Care

Study Details

Brief summary:

The purpose of this study is to evaluate clinical decision-making algorithms for (a) triaging to level of care and (b) adapting level of care in a low income, highly diverse sample of community college students at East Los Angeles College (ELAC).

The target enrollment is 200 participants per year, for five years (N=1000). Participants are between the ages of 18 and 40 years and will be randomized into either symptom severity decision-making (SSD) or data-driven decision-making (DDD). Participants in each condition will be triaged to one of three levels of care, including self-guided online prevention, coach-guided online cognitive behavioral therapy, and clinician-delivered care. After initial triaging, level of care will be adapted throughout the entire time of the study enrollment. Participants will complete computerized assessments and self-report questionnaires as part of the study. The total length of participation is 40 weeks.

Conditions

Depression

Anxiety

Study ID

NCT05591937

Start date

Aug 29, 2022

Status verified date

Feb, 2026

Completion date

Apr 30, 2027

Anticipated

Primary completion date

Apr 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 40

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Currently enrolled in the East Los Angeles College
  • Either uninsured or covered by California Medicaid
  • Own or have private access to internet to complete the assessments and online prevention and therapy programs

Exclusion Criteria:

  • Unable to fully comprehend the consent form, respond adequately to screening questions, or maintain focus or to sit still during assessment
  • Diagnosed with disorders requiring more specialized care (e.g., psychotic disorder, severe eating disorder, severe substance use disorder, severe neurological disorder), or marked cognitive impairment
  • Currently treated by psychiatrist or psychologist during timeframe that the treatment is offered through STAND and is unwilling to fully transfer care to STAND

Study Design

Enrollment

1000 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Symptom Severity Decision-Making

Using current symptom severity level to guide triaging and adapting level of care.

experimental: Data-Driven Decision-Making

Using data-driven algorithm that considers social determinants of mental health, early life adversity/stress, predisposing, enabling and need influences upon health services use, and comprehensive mental health status to guide triaging and adapting level of care.

Interventions

Self-Guided Online Prevention

An online wellness program that contains self-guided online CBT prevention strategies with demonstrated efficacy for depression and anxiety in college samples. Participants can learn skills for coping with common stressful experiences and build resilience at their own pace.

Coach-Guided Online Cognitive Behavioral Therapy

An online digital therapy program that consists of online CBT modules supported by coaches through video chats. The modules are evidence-based and formatted into a unified approach for depression, anxiety and worry, panic, social anxiety, trauma and sleep dysregulation (developed as part of the University of California, Los Angeles (UCLA) Depression Grand Challenge). Lessons are designed to respond to participants' specific symptoms. Participants can access the system through any personal device (phone, tablet or computer) and speak to a certified student coach through remote video chat.

Clinician-Delivered Psychological and Psychiatric Care

Evidence-based clinician-delivered CBT modules. Participants are connected to a team of clinicians who will evaluate participants' specific symptoms and create an individualized and tailored treatment plan. Treatment will include weekly sessions delivered through telehealth, and if deemed appropriate, participants may also have medication appointments.

Primary outcome measure

  • Longitudinal trajectory of treatment adherence [ Time Frame: Up to 40 weeks ]
  • Baseline symptom severity for mental health [ Time Frame: Baseline ]
  • Longitudinal trajectory of symptom severity for mental health [ Time Frame: Up to 40 weeks ]
  • Baseline social, occupational, and home functioning [ Time Frame: Baseline ]
  • Baseline academic functioning [ Time Frame: Baseline ]
  • Longitudinal trajectory of social, occupational, and home functioning [ Time Frame: Up to 40 weeks ]
  • Longitudinal trajectory of academic functioning [ Time Frame: Up to 40 weeks ]
  • Suicide and self-harm [ Time Frame: Up to 40 weeks ]

Central Contacts and Locations

Central contacts

Amelia Welborn, Ph.D.

916-202-5952awelborn@mednet.ucla.edu

Alainna Wen, Ph.D.

AAWen@mednet.ucla.edu

Locations

East Los Angeles College

Recruiting

Los Angeles, California, United States, 91754

Contacts

Areli Vargas

VARGASA3@ELAC.EDU

More Information

Sponsor

University of California, Los Angeles

Last update posted

Feb 5, 2026

Last verified

Feb, 2026

Keywords

  • personalized care
  • cognitive behavioral therapy
  • depression
  • anxiety

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, Los Angeles on 2026-02-05.