Recruiting

Peg-the-Mole

Sponsor:

Nova Scotia Health Authority

Code:

NCT05595668

Conditions

Spatial Neglect

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Interventions

Prism Adaptation - 15-degree prism goggles

Prism Adaptation - 5-degree prism goggles

Study Details

Brief summary:

Spatial neglect is a common disorder after stroke which leads to problems with noticing or responding to information from the left side of the body or space. This condition has been linked to reduced independence in a wide range of daily life activities including eating, dressing, and mobility. Despite its high prevalence in stroke patients, there is currently no standard of care for spatial neglect. Prism adaptation (PA) is a promising treatment, however, there are limitations to using PA in standard clinical care as it requires daily exposure for at least two weeks, yet access to equipment and supervision is limited. To solve this problem, the investigators have developed a new game-like PA treatment (Peg-the-Mole, PTM) that can be used at home without the need for daily in person therapist set-up and supervision. In this study the investigators aim to evaluate the feasibility and effectiveness of the gamified and portable PA procedure in an inpatient and home setting, with the hypothesis that the PA procedure will improve patient's neglect symptoms.

Conditions

Spatial Neglect

Study ID

NCT05595668

Start date

Sep 15, 2023

Status verified date

Jul, 2025

Completion date

Nov, 2026

Anticipated

Primary completion date

Nov, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 0+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Have experienced a right hemisphere stroke (confirmed by a clinician)
2. Experience mild to severe symptoms of neglect
3. Be willing and able to consent to participate
4. Be medically stable
5. Have self-reported normal to corrected-to-normal vision
6. Be able to point to targets presented on a computer screen
7. Live within a two-hour radius of Halifax

Exclusion Criteria:

Other existing neurological disorders (e.g., dementia, multiple sclerosis, epilepsy).

Study Design

Enrollment

80 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Prism adaptation treatment

Prism Goggles with 15-degree rightward deviating prism lenses will be used to implement prism adaptation treatment, in addition to standard care.

placebo comparator: Placebo control prism adaptation treatment

Prism goggles with 5-degree rightward deviating prism lenses will be used to maintain the double-blind methodology.

Interventions

Prism Adaptation - 15-degree prism goggles

Patients in the experimental condition will wear prism goggles while completing an iPad-administered aiming task. The prisms will shift the patients' vision 15 degrees rightward, causing a recalibration of visuo-motor information. Prism adaptation will be carried out for ten sessions for 15 minutes a day, over the span of two weeks.

Prism Adaptation - 5-degree prism goggles

5-degree goggles are worn instead of the 15-degree prism goggles, while completing the same tasks as those assigned to the 15-degree condition.

Primary outcome measure

  • Test of neglect severity 1 [ Time Frame: taken at baseline (immediately before the intervention), immediately after the intervention, and one month after the intervention ]
  • Test of neglect severity 2 [ Time Frame: measured immediately before and immediately after each intervention session ]
  • Test of neglect severity 3 [ Time Frame: taken at baseline (immediately before the intervention), immediately after the intervention, and one month after the intervention ]
  • Test of neglect impact on daily activities [ Time Frame: taken at baseline (immediately before the intervention), immediately after the intervention, and one month after the intervention ]
  • Scale of neglect impact on daily activities [ Time Frame: taken at baseline (immediately before the intervention), immediately after the intervention, and one month after the intervention ]
  • Measure of feasibility Measure of feasibility [ Time Frame: logged immediately following each intervention session through training logs ]
  • Measure of feasibility 2 [ Time Frame: collected immediately after the intervention ]

Central Contacts and Locations

Central contacts

Anne Sophie Champod, PhD

9028176871anne.champod@acadiau.ca

Locations

Nova Scotia Health Early Supported Stroke Discharge Team

Recruiting

Bedford, Nova Scotia, Canada, B3H 4K4

Contacts

Joy Boyce

902-473-7361joy.boyce@nshealth.ca

Nova Scotia Rehabilitation and Arthritis Centre

Recruiting

Halifax, Nova Scotia, Canada, B3H 4K4

Contacts

Matthew Miller

902-473-7361MatthewD.Miller@nshealth.ca

Valley Regional Hospital

Recruiting

Kentville, Nova Scotia, Canada, B4N 5E3

Contacts

Kyla Harris

902-698-3263kyla.harris2@nshealth.ca

More Information

Sponsor

Nova Scotia Health Authority

Last update posted

Jul 30, 2025

Last verified

Jul, 2025

Keywords

  • Spatial Neglect
  • Prism Adaptation
  • Rehabilitation
  • Stroke

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Nova Scotia Health Authority on 2025-07-30.