Recruiting

Beet-root Juice & PBM

Sponsor:

Wake Forest University

Code:

NCT05596474

Conditions

Health Care Utilization

Healthy Aging

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Interventions

Beet-root juice

red-light therapy

Placebo

sham light

Study Details

Brief summary:

The goal of this randomized counterbalanced repeated measures study is to test beet-root juice supplementation and red light therapy augment forearm muscle endurance in apparently healthy older adults over 65 years of age. The main questions seek to answer the following question:

Does beet-root juice supplementation improve forearm muscle endurance compared to a placebo supplement?

Does red light therapy improve forearm muscle endurance compared to a sham light exposure?

Does beet-root juice supplementation in combination with red light therapy improve forearm muscle endurance compared to a placebo-sham light control?

Conditions

Health Care Utilization

Healthy Aging

Study ID

NCT05596474

Start date

Sep 9, 2022

Status verified date

Mar, 2024

Completion date

Aug 31, 2024

Anticipated

Primary completion date

Aug 31, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 65+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-reports performing at least 30 minutes of light to moderate intensity physical activity 3 times per week for the last three months

Exclusion Criteria:

  • Currently smoke
  • Have smoked within the last 6 months
  • Are taking taking supplements known to increase blood nitrate levels
  • Have a known kidney disease
  • Have a known liver disease
  • Have a known thyroid condition
  • Have a known gastritis condition
  • Are taking medications that are known to cause complications with nitrate supplementation
  • Have known or reported joint pain within the dominant hand

Study Design

Enrollment

10 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Beet-root juice plus red-light therapy

sham comparator: Beet-root juice plus sham light therapy

placebo comparator: Placebo plus red-light therapy

active comparator: Placebo plus sham light therapy

Interventions

Beet-root juice

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a 400mg nitrate once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third 400mg dose of nitrates at least 150 minutes before forearm endurance testing.

red-light therapy

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to 660nm wave length light for 10-minutes.

Placebo

Two days prior to the forearm endurance protocol, participants will be provided and instructed to consume a nitrate depleted placebo once per day. On the day of the forearm endurance protocol, the participants will be provided and instructed to consume a third dose of the nitrate depleted placebo at least 150 minutes before forearm endurance testing.

sham light

Participants will place their dominant forearm 15 centimeters away from the light source and have their dominant forearm exposed to sham light for 10-minutes.

Primary outcome measure

  • Total forearm work performed [ Time Frame: During the forearm exercise fatigue protocol lasting up to 45 minutes ]

Central Contacts and Locations

Central contacts

Andrew D Wells, Ph.D.

(336) 758-5837wellsa@wfu.edu

Locations

Wake Forest Univesity

Recruiting

Winston-Salem, North Carolina, United States, 27106

Contacts

Andrew D Wells, Ph.D.

336-758-5837wellsa@wfu.edu

More Information

Sponsor

Wake Forest University

Last update posted

Mar 20, 2024

Last verified

Mar, 2024

Keywords

  • Red light therapy
  • Forearm muscle endurance
  • Beet-root juice
  • Electromyography

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Wake Forest University on 2024-03-20.