Recruiting

TcMS

Sponsor:

University of Pennsylvania

Code:

NCT05599022

Conditions

Ventricular Tachycardia

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Magnetic Stimulation

Study Details

Brief summary:

Three-arm randomized clinical trial comparing two strategies of TcMS to sham stimulation in patients with VT storm. The hypothesis of the study is that TcMS will reduce the burden of VT in the 24 hours after randomization compared to sham stimulation and that TcMS with theta burst stimulation (TBS) will be more effective at reducing VT burden than low frequency TcMS.

Conditions

Ventricular Tachycardia

Study ID

NCT05599022

Start date

May 22, 2023

Status verified date

Apr, 2026

Completion date

Oct, 2028

Anticipated

Primary completion date

Jul, 2028

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • ≥3 episodes of sustained VT or appropriate ICD therapies within 24 hours despite the use of at least one antiarrhythmic drug

Exclusion Criteria:

  • Plan for catheter ablation of VT in the next 24 hours
  • Pregnancy
  • Contraindication to TcMS (i.e. implantable ventricular assist device, metal implanted in the head or neck \[except the mouth\], implanted medication pumps, cochlear implant, implanted brain stimulator, ocular implant, history of malignancy in the neck)

Study Design

Enrollment

60 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

placebo comparator: Sham Stimulation

With the coil directed away from the patient, 600 pulses of TcMS will be delivered at minimal energy output.

active comparator: Low Frequency TcMS

With the coil directed at the stellate ganglion, 60 minutes of 1Hz stimulation will be delivered targeting the stellate ganglion.

active comparator: Theta Burst Stimulation TcMS

With the coil directed at the stellate ganglion, 600 pulses of continuous theta burst stimulation will be delivered targeting the stellate ganglion.

Interventions

Magnetic Stimulation

Transcutaneous Magnetic Stimulation

Primary outcome measure

  • VT Burden (24 hours) [ Time Frame: 24 hours after randomization ]

Central Contacts and Locations

Central contacts

Timothy Markman

215-615-4332timothy.markman@pennmedicine.upenn.edu

Locations

Hospital of the University of Pennsylvania

Recruiting

Philadelphia, Pennsylvania, United States, 19104

More Information

Sponsor

University of Pennsylvania

Last update posted

Apr 21, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by University of Pennsylvania on 2026-04-21.