Recruiting

Observational Study

Sponsor:

Abramson Cancer Center at Penn Medicine

Code:

NCT05612789

Conditions

Allogeneic Transplantation

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Interventions

Exercise Program (Cohort A Prehab)

Exercise Program (Cohort B Rehab)

Study Details

Brief summary:

This is an interventional pilot study to determine whether implementation of a supervised exercise program can improve outcomes in subjects undergoing allogeneic HCT. The primary objective is to determine feasibility. Up to 60-72 evaluable subjects will be enrolled. Evaluable subjects are defined as those participating in the exercise intervention.

Conditions

Allogeneic Transplantation

Study ID

NCT05612789

Start date

Feb 15, 2023

Status verified date

Dec, 2025

Completion date

Jun 1, 2031

Anticipated

Primary completion date

Jun 1, 2030

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Cohort A (Prehab)

1. Age 60 years or older.
2. Planned allogeneic HCT in the next 1-6 months.
3. Hematological malignancy as the indication for HCT.
4. Pre-frail or frail by Fried frailty phenotype.

Cohort B (Rehab)

1. Age 60 years or older.
2. Planned allogeneic HCT or HCT within the last 30 days.
3. Hematological malignancy as the indication for HCT.

Exclusion Criteria:

Cohorts A and B

1\. Comorbid disability or illness that prevents safe exercise.

Study Design

Enrollment

72 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Cohort A (Prehab)

Pre-frail and frail subjects will attend at least twice weekly exercise sessions with a physical therapist and be given an exercise program to complete at home prior to admission for HCT. Patients enrolled in this cohort can continue on to Cohort B.

experimental: Cohort B (Rehab)

All patients 60 years and older upon discharge from their initial hospital stay for HCT will attend at least weekly exercise sessions with a physical therapist and be given an exercise program to complete at home with sessions continued through Day +100 after HCT.

Interventions

Exercise Program (Cohort A Prehab)

Pre-frail and frail potential HCT recipients 60 years and older will participate in a supervised exercise program from the time of enrollment up until HCT admission. Exercise compliance will be measured in part through physical activity trackers.from time of discharge from HCT until day +100 post-HCT. All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.

Exercise Program (Cohort B Rehab)

All HCT recipients 60 years and older will participate in a supervised exercise program from the time of discharge from HCT admission until day +100 post-HCT. Exercise compliance will be measured in part through physical activity trackers.

Primary outcome measure

  • Proportion of enrolled subjects who participate in the supervised exercise program [ Time Frame: From 3 months prior to HCT to 100 days after HCT ]
  • Median number of exercise sessions delivered pre-HCT and post-HCT. [ Time Frame: From 3 months prior to HCT to 100 days after HCT ]

Central Contacts and Locations

Central contacts

Jacqui Rick

2152209675Jacqui.Rick@pennmedicine.upenn.edu

Locations

Penn Medicine

Recruiting

Philadelphia, Pennsylvania, United States, 19104

Contacts

Jacqui Rick

215-220-9675Jacqui.Rick@pennmedicine.upenn.edu

More Information

Sponsor

Abramson Cancer Center at Penn Medicine

Last update posted

Dec 10, 2025

Last verified

Dec, 2025

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Abramson Cancer Center at Penn Medicine on 2025-12-10.