Recruiting

StableEyes

Sponsor:

Johns Hopkins University

Code:

NCT05622344

Conditions

Vestibular Disorder

Vestibular Schwannoma

Space Motion Sickness

Motion Sickness

Eligibility Criteria

Sex: All

Age: 21 - 70

Healthy Volunteers: Accepted

Interventions

Traditional Therapy

SWAN

Study Details

Brief summary:

The investigators have developed a self-administered rehabilitation tool that incrementally guides the user to increase head motion to mitigate motion sickness and enhance postural recovery following centrifugation or unilateral vestibular nerve deafferentation surgery.

Conditions

Vestibular Disorder

Vestibular Schwannoma

Space Motion Sickness

Motion Sickness

Study ID

NCT05622344

Start date

Aug 8, 2022

Status verified date

Sep, 2026

Completion date

Mar 30, 2027

Anticipated

Primary completion date

Mar 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 21 - 70

Healthy Volunteers: Accepted

Inclusion Criteria:

1. Provision of signed and dated informed consent form
2. Stated willingness to comply with all study procedures and availability for the duration of the study
3. In good general health as evidenced by medical history or diagnosed with unilateral vestibular schwannoma
4. Willing to adhere to the SWAN and/or vestibular rehabilitation regimen

Exclusion Criteria:

1. Current use of anti-nausea medication
2. Presence of cervical spine pathology that limits head motion to < 30 degrees in the horizontal or vertical plane (i.e. degenerative disc disease, rheumatoid arthritis)
3. Any orthopedic pathology that prevents walking or standing independently (i.e. recent surgery)
4. Legal blindness (20/200 or worse visual acuity)
5. Treatment using a motion sickness investigational drug or other motion sickness behavioral intervention within 30 days

Study Design

Enrollment

48 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Traditional Vestibular Physical Therapy (VPT) JHU

Subjects that have had their eighth cranial nerve resected will receive traditional vestibular rehabilitation exercises at Johns Hopkins University (JHU) site.

experimental: SWAN VPT JHU

Subjects that have had their eighth cranial nerve resected will receive the automated vestibular rehabilitation method

experimental: SWAN Motion Sick Dayton

Healthy control subjects that meet similar similar physical characteristics of astronauts will receive the automated vestibular rehabilitation method post motion sickness.

no intervention: Traditional Motion Sick Dayton

Typically, the suggestion for treating motion sickness once it has started is to avoid motion. Therefore, healthy control subjects that meet similar similar physical characteristics of astronauts will not receive any post motion sickness treatment.

Interventions

Traditional Therapy

Exercises that teaches subjects to move their heads while viewing still or moving targets.

SWAN

The SWAN device uses video-oculography to monitor head motion while guiding participants to move their head in yaw, pitch, roll planes for 15 minutes. Feedback is provided regarding frequency and plane of head rotation

Primary outcome measure

  • Change in Motion sickness intensity as assessed by subjective rating [ Time Frame: Daily for up to 4 weeks ]

Central Contacts and Locations

Central contacts

Michael Schubert, PhD

4108427403mschube1@jhmi.edu

Matthew Stewart, MD PhD

4109553492cstewa16@jhmi.edu

Locations

Johns Hopkins University

Recruiting

Baltimore, Maryland, United States, 21287

Contacts

Michael C Schubert, PhD

410-955-3403mschube1@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Sep 8, 2026

Last verified

Sep, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-09-08.