Recruiting

Soft Tissue Grafting

Sponsor:

Tufts University

Code:

NCT05633511

Conditions

Gingival Recession

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Split Mouth Design

Study Details

Brief summary:

To correct gum recession, patient's own tissue from the roof of the mouth is harvested and placed where there is root exposed. This is considered gold standard of treatment. Sometimes patient don't want to have second surgical site in their mouth and at the same time do not want to use alternative tissue from human or animal donor. Using patients' blood and preparing it as a membrane is the next best thing to correct gum recession.

Conditions

Gingival Recession

Study ID

NCT05633511

Start date

Jan 11, 2023

Status verified date

Apr, 2026

Completion date

Dec 30, 2036

Anticipated

Primary completion date

Dec 30, 2035

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Adults 18yrs or older
2. Need of MG-tx for 2 or more sites for root coverage RT I and II (Cairo classification)
3. Class A +/-
4. No class V restoration present

Exclusion Criteria:

1. Patients who do not consent to recommended therapy
2. Patients who smoke
3. Patients who will not be able to comply with follow up protocols
4. Those who self report that they are pregnant.

Study Design

Enrollment

50 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: All Participants

Participants will receive the CTG procedure on one side and the PRF procedure on the other. Both are standard of care soft tissue grafting methods and a split mouth design is standard of care.

Interventions

Split Mouth Design

PRF on one side of mouth and CTG on the other side of participant's mouth.

Primary outcome measure

  • Compare autologous PRF & Autogenous CTG [ Time Frame: 5 years ]

Central Contacts and Locations

Central contacts

Tannaz Shapurian, DDM, MSc

617.636. 6741Tannaz.shapurian@tufts.edu

Ann-Marie Jacobson

6176363751ann-marie.billig@tufts.edu

Locations

Tufts University School of Dental Medicine

Recruiting

Boston, Massachusetts, United States, 02111

Contacts

Tannaz Shapurian

tannaz.shapurian@tufts.edu

More Information

Sponsor

Tufts University

Last update posted

Apr 29, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Tufts University on 2026-04-29.