Recruiting

CINB

Sponsor:

Zachary Warriner

Code:

NCT05642026

Conditions

Rib Fractures

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Ropivacaine

Non steroidal anti-inflammatory drug and opioids

Study Details

Brief summary:

This is a prospective, randomized, non-blinded study comparing CINB plus medical therapy versus standard medical care (non-steroidals and opioids intravenous/oral inpatient and oral outpatient) alone for patients with multiple rib fractures. The objective of this study is to analyze the effect of continuous intercostal nerve block (CINB) in the treatment of patients admitted to the adult trauma service with rib fractures. The effectiveness of CINB as adjunctive treatment will be compared to standard medical therapy involving nonsteroidal and intravenous/oral opioid medications.

Conditions

Rib Fractures

Study ID

NCT05642026

Start date

Sep 23, 2025

Status verified date

Sep, 2025

Completion date

Feb 1, 2027

Anticipated

Primary completion date

Feb 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Subjects will be at least 18 years old
  • Subjects will have 2 or more identified rib fractures
  • Subjects will be willing to provide informed consent for procedure
  • Subjects will be identified as appropriate for initiation of continuous nerve block therapy for treatment of rib fracture associated pain.

Exclusion Criteria:

  • Documented allergy to study medication
  • Epidural catheter use
  • Prisoners
  • Refusal of CINB therapy

Study Design

Enrollment

180 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: continuous intercostal nerve block (CINB)

patients admitted to the adult trauma service with rib fractures who are receiving CINB

active comparator: standard medical care

patients admitted to the adult trauma service with rib fractures who are receiving standard medical care

Interventions

Ropivacaine

Patients in this group will receive CINB (continuous local intercostal infusion of 0.2% Ropivacaine). A single catheter will be placed for short segment involvement and two catheters will be placed in series for longer segments of involvement. If necessary and as part of standard of care, CINB treatment will continue after patient discharge. The administration of CINB therapy will continue in the same manner as inpatient therapy.

Non steroidal anti-inflammatory drug and opioids

Patients in this group receive nonsteroidal and opioid pain medications (intravenous/oral inpatient and oral outpatient) per standard of care.

Primary outcome measure

  • Length of hospital stay [ Time Frame: 7 days ]

Central Contacts and Locations

Locations

University of Kentucky Medical Center

Recruiting

Lexington, Kentucky, United States, 40536

Contacts

Zachary D Warriner, MD

8593238222ZACHARYDWARRINER@UKY.EDU

Principal Investigator:

zACHARY D WARRINER, MD

More Information

Sponsor

Zachary Warriner

Last update posted

Oct 7, 2025

Last verified

Sep, 2025

Keywords

  • intercostal
  • nerve block
  • opioid
  • non steroidal
  • inpatient
  • outpatient
  • catheter
  • anesthetic
  • epidural

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Zachary Warriner on 2025-10-07.