Recruiting

Circuit-Based DBS

Sponsor:

University of Minnesota

Code:

NCT05658302

Conditions

Parkinson Disease

Eligibility Criteria

Sex: Female

Age: 21+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study will help us better understand how the brain works in people with Parkinson's disease (PD). PD is a brain disease that gets worse over time, and affects over 10 million people world-wide. A common treatment for PD is Deep Brain Stimulation (DBS). To improve DBS therapy for PD, we need a deeper understanding of how the different parts of the brain work together in PD, and how this relates to movement and thinking problems that people with PD experience.

We may be able to use the results of this study to improve DBS treatments in the future.

Conditions

Parkinson Disease

Study ID

NCT05658302

Start date

Mar 28, 2023

Status verified date

Jan, 2026

Completion date

Mar 1, 2028

Anticipated

Primary completion date

Mar 1, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 21+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Diagnosis of idiopathic PD
  • Surgery at UMN to implant DBS system with directional lead(s) and multiple independent current control IPG is planned as part of routine clinical care
  • At least 21 years old

Exclusion Criteria:

  • Other significant neurological disorder
  • History of dementia
  • Patients with post-operative complications or adverse effects (e.g. ON stimulation dystonias) that affect patient safety or confound the experiment will be excluded from further study
  • Pregnant women
  • Known radiation exposure within the last year that is determined to be unsafe when compounded with the expected radiation dose from intraoperative fluoroscopy to place ECoG strip

Study Design

Enrollment

30 participants

Anticipated

Interventions and Outcome Measures

Arms

Parkinson's disease

  • Diagnosis of idiopathic PD
  • Surgery at UMN to implant DBS system with directional lead(s) and multiple independent current control IPG is planned as part of routine clinical care
  • At least 21 years old
  • Existing or planned 7T brain imagery

Primary outcome measure

  • reach-related modulation [ Time Frame: 2 days ]
  • N-back task trials [ Time Frame: 2 days ]
  • rigidity and bradykinesia assessments [ Time Frame: 1 day ]
  • peak frequency of the ERs + spontaneous LFPs [ Time Frame: 1 day ]

Central Contacts and Locations

Central contacts

Emily Weatherill

612-625-4947weath210@umn.edu

Locations

University Of Minnesota

Recruiting

Minneapolis, Minnesota, United States, 55445

More Information

Sponsor

University of Minnesota

Last update posted

Jan 26, 2026

Last verified

Jan, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Minnesota on 2026-01-26.