Recruiting

Cell-free DNA

Sponsor:

M.D. Anderson Cancer Center

Code:

NCT05676450

Conditions

Lymphoma

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

cell-free DNA

Study Details

Brief summary:

To test the feasibility of collecting cell-free DNA (cfDNA) samples from DLBCL patients before and after treatment. cfDNA is DNA traveling in your blood outside of a cell and is easily collected from blood samples drawn using the vein puncture method.

Conditions

Lymphoma

Study ID

NCT05676450

Start date

Feb 23, 2023

Status verified date

May, 2026

Completion date

Aug 31, 2026

Anticipated

Primary completion date

Aug 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. Male/female patients who are at least 18 years of age on the day of informed consent signing.
2. Patients must have a histologically documented diffuse large B-cell lymphoma requiring therapy.
3. Provision of written informed consent for the study.
4. Pregnant women not included
5. Cognitively impaired adults are not included.

Exclusion Criteria:

None

Study Design

Enrollment

517 participants

Anticipated

Intervention Model

Single group

Primary purpose

Diagnostic

Interventions and Outcome Measures

Arms

other: cell-free DNA (cfDNA) samples

cell-free DNA (cfDNA) samples from DLBCL participants before and after treatment. cfDNA is DNA traveling in your blood outside of a cell and is easily collected from blood samples drawn using the vein puncture method.

Blood will be drawn 3 times (by vein)

Interventions

cell-free DNA

Given by IV (vein)

Primary outcome measure

  • Overall Survival (OS) [ Time Frame: through study completion; an average 1 year ]

Central Contacts and Locations

Central contacts

Chijioke Nze, MD

832-729-1752CCNze@mdanderson.org

Locations

MD Anderson Cancer Center

Recruiting

Houston, Texas, United States, 77030

Contacts

Chijioke Nze, MD

832-729-1752CCNze@mdanderson.org

Principal Investigator:

Chijioke Nze, MD

Cancer Therapy and Research Center at The UT Health Science Center at San Antonio

Recruiting

San Antonio, Texas, United States, 78229

Contacts

Adolfo Enriques Diaz Duque, MD

210-450-1209diazduque@uthscsa.edu

Principal Investigator:

Adolfo Enriques Diaz Duque, MD

More Information

Sponsor

M.D. Anderson Cancer Center

Last update posted

May 20, 2026

Last verified

May, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by M.D. Anderson Cancer Center on 2026-05-20.