Recruiting

Observational Study

Sponsor:

Mayo Clinic

Code:

NCT05699200

Conditions

Spontaneous Coronary Artery Dissection

Healthy

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Accepted

Interventions

Arterial Tonometry

Echocardiogram

Carotid Ultrasounds

Elastography

Ankle-Brachial Index

Study Details

Brief summary:

The purpose of this research is to compare sympathetic function (flight or fight system) and arterial health including structure and mechanics of participants with history of spontaneous coronary artery dissection (SCAD) to age and sex matched control participants.

Conditions

Spontaneous Coronary Artery Dissection

Healthy

Study ID

NCT05699200

Start date

Jun 1, 2023

Status verified date

Jun, 2026

Completion date

Aug, 2027

Anticipated

Primary completion date

Aug, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: Female

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • For SCAD patients: history of SCAD as confirmed by coronary angiography or cardiac computed tomography angiography
  • For controls: no cardiac disease history

Exclusion Criteria:

  • Pregnancy
  • Known or suspected unstable cardiac condition within 4 weeks of the study
  • Active treatment with anticoagulation or dual antiplatelet therapy
  • Prisoner

Study Design

Enrollment

50 participants

Anticipated

Allocation

Non randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

other: Spontaneous coronary artery dissection (SCAD) group

Subject with a history of SCAD will undergo a series of diagnostic studies to assess neurovascular function.

other: Healthy Control Group

Healthy subjects will undergo a series of diagnostic studies to assess neurovascular function.

Interventions

Arterial Tonometry

We will measure arterial stiffness using arterial tonometry.

Echocardiogram

We will collect limited ultrasound images of the heart.

Carotid Ultrasounds

We will perform ultrasound imaging of the carotid artery.

Elastography

We will measure the elastic properties of the arteries using elastography.

Ankle-Brachial Index

We will measure the ankle-brachial index to assess peripheral artery blood flow.

Microneurography with sympathoexcitatory maneuvers

We will measure sympathetic nerve activity at rest and in response to isometric handgrip, mental stress test, cold pressor test, Valsalva maneuvers.

Primary outcome measure

  • Arterial thickness [ Time Frame: Baseline ]
  • Arterial stiffness [ Time Frame: Baseline ]
  • Baroreflex sensitivity [ Time Frame: Baseline ]
  • Sympathetic response to stress [ Time Frame: Baseline ]

Central Contacts and Locations

Central contacts

Pamela Engrav

507-255-6938Engrav.Pamela@mayo.edu

Locations

Mayo Clinic Rochester

Recruiting

Rochester, Minnesota, United States, 55905

More Information

Sponsor

Mayo Clinic

Last update posted

Jun 17, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Mayo Clinic on 2026-06-17.