Recruiting

Observational Study

Sponsor:

Johns Hopkins University

Code:

NCT05703386

Conditions

Ischemic Stroke

Hypertension

Hyperlipidemias

Diabetes

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Study Details

Brief summary:

Cerebral small vessel disease (CSVD) can lead to vascular cognitive impairment and dementia (VCID). The hallmark of CSVD is the appearance and progression of white matter hyperintensities (WMH) on MRI. The goal of this study it to recruit and follow individuals at risk for WMH progression and use serial MRI scanning to gain insights into the pathogenesis of CSVD.

Conditions

Ischemic Stroke

Hypertension

Hyperlipidemias

Diabetes

Study ID

NCT05703386

Start date

Nov 8, 2022

Status verified date

Mar, 2026

Completion date

Mar 31, 2027

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Clinical or radiographic evidence of ischemic stroke
  • One vascular risk factor (hypertension, hyperlipidemia, or diabetes)
  • Evidence of cerebral small vessel disease on MRI

Exclusion Criteria:

  • Inability to complete 3 research MRI scans over 1.25 years

Study Design

Enrollment

50 participants

Anticipated

Interventions and Outcome Measures

Primary outcome measure

  • Progression of cerebral small vessel disease [ Time Frame: 1 year ]

Central Contacts and Locations

Central contacts

Sera Chase

410-502-5355schase15@jh.edu

Locations

Kennedy Krieger Institute

Recruiting

Baltimore, Maryland, United States, 21205

Contacts

Pooja Patel

410-502-5355ppate120@jhmi.edu

More Information

Sponsor

Johns Hopkins University

Last update posted

Mar 3, 2026

Last verified

Mar, 2026

Keywords

  • Cerebral small vessel disease
  • Vascular cognitive impairment and dementia
  • White matter hyperintensities
  • Blood-brain barrier
  • Vascular risk factors
  • Ischemic stroke

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Johns Hopkins University on 2026-03-03.