Recruiting

Observational Study

Sponsor:

Michigan State University

Code:

NCT05707923

Conditions

Autism Spectrum Disorder

Eligibility Criteria

Sex: All

Age: 1 - 4

Healthy Volunteers: Not accepted

Interventions

Linguistic simplification

Study Details

Brief summary:

The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with ASD. The overall objective is to determine how single-word and telegraphic simplification affects real-time language processing and word learning in young children with ASD (relative to full, grammatical utterances). The proposed project will investigate three specific aims: 1) Determine how single-word and telegraphic simplification affects language processing. 2) Determine how single-word and telegraphic simplification affects word learning. 3) Evaluate child characteristics that may moderate the effects of linguistic simplification on language processing and word learning. Aim 1 will test the hypothesis that children with ASD will process full, grammatical utterances faster and more accurately than single-word or telegraphic utterances. Aim 2 will test the hypothesis that full, grammatical utterances will support word learning better than telegraphic or single-word utterances. Aim 3 will test the hypothesis that language and cognitive skills significantly moderate the effects of linguistic simplification on language processing and word learning in young children with ASD.

Conditions

Autism Spectrum Disorder

Study ID

NCT05707923

Start date

Jun 1, 2023

Status verified date

Jun, 2026

Completion date

May 31, 2027

Anticipated

Primary completion date

May 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 1 - 4

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Existing or suspected autism spectrum disorder, confirmed through ADOS-2
  • English as primary language
  • 1-4 years old

Exclusion Criteria:

  • Known genetic condition (e.g., Down syndrome, fragile X)
  • Cerebral palsy
  • Acquired brain injury
  • Uncorrected vision or hearing impairment

Study Design

Enrollment

104 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Utterance Type

This study uses a within-participant experimental manipulation. All participants will be exposed to all utterance types (across trials).

Interventions

Linguistic simplification

Children will participate in screen-based language processing and word learning tasks in which they hear utterances with different types and amounts of linguistic simplification (i.e., a within-group manipulation).

Primary outcome measure

  • Gaze location on Looking-While-Listening (LWL) tasks [ Time Frame: Single assessment per task; total duration less than 10 minutes per task ]

Central Contacts and Locations

Central contacts

Courtney Venker, PhD

5178842259cvenker@msu.edu

Locations

Michigan State University

Recruiting

East Lansing, Michigan, United States, 48824

Contacts

Courtney Venker, PhD

5178842259cvenker@msu.edu

More Information

Sponsor

Michigan State University

Last update posted

Jun 15, 2026

Last verified

Jun, 2026

Keywords

  • language
  • autism
  • intervention
  • processing
  • learning
  • early childhood
  • treatment
  • early intervention
  • telegraphic
  • language input
  • looking-while-listening
  • eye tracking
  • comprehension
  • neurodevelopmental disorders

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-08. This information was provided to ClinicalTrials.gov by Michigan State University on 2026-06-15.