Recruiting

UPURS

Sponsor:

UCLA

Code:

NCT05715086

Conditions

Ureteral Stone

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Ureteroscopy

Study Details

Brief summary:

A prospective, non-blinded, randomized controlled trial studying the management of symptomatic ureteral stones. This study will compare upfront ureteroscopy vs observation and delayed intervention for patients presenting to the emergency department with a symptomatic ureteral stone.

Conditions

Ureteral Stone

Study ID

NCT05715086

Start date

Aug 23, 2023

Status verified date

Jan, 2025

Completion date

Jun 30, 2026

Anticipated

Primary completion date

Jun 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Presenting to the Emergency Department (ED)
  • Adult (> 18 yo)
  • ≥5mm ureteral stone diagnosed on CT scan
  • Presence of symptoms (pain, nausea, vomiting, hematuria)

Exclusion Criteria:

  • Strict indication for stent
  • Stone burden not amenable to Ureteroscopy (URS)
  • Dirty urine analysis (UA) or positive urine culture (UCx)
  • Transplant kidney
  • Presence of conduit
  • Comorbidities not optimized for surgery
  • Strong preference for surgery or observation

Study Design

Enrollment

100 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

active comparator: Group A (Upfront ureteroscopy)

no intervention: Group B (Observation/delayed ureteroscopy)

Interventions

Ureteroscopy

Upfront ureteroscopy

Primary outcome measure

  • Pain Score [ Time Frame: 3 months ]
  • Anxiety Score [ Time Frame: 3 months ]

Central Contacts and Locations

Central contacts

Catherine Arevalo, BA

415-514-0918catherine.arevalo@ucsf.edu

Heiko Yang, MD

heiko.yang@ucsf.edu

Locations

University of California, San Francisco

Recruiting

San Francisco, California, United States, 94143

Contacts

Tom Chi, MD

tom.chi@ucsf.edu

Heiko Yang, MD

513-8862172heiko.yang@ucsf.edu

More Information

Sponsor

University of California, San Francisco

Last update posted

Jan 17, 2025

Last verified

Jan, 2025

Keywords

  • Symptomatic ureteral stones

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of California, San Francisco on 2025-01-17.