Recruiting

Kidney Transplant

Sponsor:

Indiana University

Code:

NCT05717842

Conditions

Transplant

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Nuclear Medicine Scan

Study Details

Brief summary:

The purpose of the study is to determine how much a persons kidney function recovers after receiving a simultaneous liver kidney transplant. The investigators will be contacting patients with kidney dysfunction with estimated GFR between 25 and 40 (not on dialysis treatment) who are listed to receive a simultaneous liver kidney (SLK) transplant to look at this function recovery. The investigators hope to develop a criteria based on GFR measurement, kidney function calculations from native kidneys vs transplanted kidney and compare the contributions, and correlate with estimated GFR on basic metabolic panel (BMP: a blood test) to predict higher chances of recovery of native kidney function.

Conditions

Transplant

Study ID

NCT05717842

Start date

Dec 8, 2023

Status verified date

Mar, 2026

Completion date

Feb, 2027

Anticipated

Primary completion date

Dec, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

1. > 18 years old
2. Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis at time of transplant surgery)
3. Candidates with two native kidneys.
4. Willing to participate and sign informed consent form.

Exclusion Criteria:

1. Unstable patients (e.g. in the ICU or those who are on Continuous Renal Replacement Therapy (CRRT) who cannot complete the nuclear medicine scan or those with AKI on Hemodialysis
2. Prior history of any solid organ transplant.
3. Those who are currently pregnant or breast feeding.
4. Patients who have Autosomal Dominant polycystic kidney disease

Study Design

Enrollment

15 participants

Anticipated

Interventions and Outcome Measures

Arms

People with ESLD and eGFR between >=25 and <=40ml/min

1. > 18 years old
2. Listed for Liver Transplant for ESLD and Kidney Transplant (not on dialysis)
3. Candidates with two native kidneys.
4. Willing to participate and sign informed consent

Interventions

Nuclear Medicine Scan

Mercaptoacetyltriglycine 3 (Mag 3) Nuclear Medicine Scan

Primary outcome measure

  • perform a nuclear medicine scan prior to SLK transplant [ Time Frame: up to 100 weeks ]

Central Contacts and Locations

Central contacts

Mary Balmes-Fenwick, B.S.

317-948-7772mbalmes@iu.edu

Locations

IU Health University Hospital

Recruiting

Indianapolis, Indiana, United States, 46202

Principal Investigator:

Muhammad Y Jan

More Information

Sponsor

Indiana University

Last update posted

Mar 12, 2026

Last verified

Mar, 2026

Keywords

  • Liver
  • Kidney

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by Indiana University on 2026-03-12.