Recruiting

Observational Study

Sponsor:

University of Oklahoma

Code:

NCT05723081

Conditions

Discrimination, Racial

Stress Physiology

Pain

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Study Details

Brief summary:

The goal of this observational study is to learn about the relationship between environmental structural racism and discrimination and chronic pain risk in Native American adults. The main questions it aims to answer are:

1. How does environmental structural racism and discrimination affect chronic pain-promoting mechanisms in Native Americans?
2. What psychosocial factors buffer the negative effects of environmental structural racism and discrimination on chronic pain-promoting mechanisms?

Conditions

Discrimination, Racial

Stress Physiology

Pain

Study ID

NCT05723081

Start date

Feb 3, 2023

Status verified date

Mar, 2025

Completion date

Mar 31, 2027

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Self-identify as Native American/American Indian

Exclusion Criteria:

  • <18 years of age
  • Self-reported history of cardiovascular, neuroendocrine, musculoskeletal, or neurological disorders
  • Surrent chronic pain, defined as persistent, bothersome pain on more days than not for at least 3 months)
  • Self-reported current substance dependence
  • Sse of medication that could interfere with testing (e.g., recent use of analgesics, antidepressants, or anti-anxiety medications)
  • Inability to speak English
  • Current psychosis (assessed by Psychosis Screening Questionnaire)
  • Serious cognitive impairment (assessed by <20 score on the Montreal Cognitive Assessment \[MoCA\])
  • Possible peripheral neuropathy (assessed by nerve conduction study)

Study Design

Enrollment

220 participants

Anticipated

Interventions and Outcome Measures

Arms

Native Americans

Native Americans / American Indians

Primary outcome measure

  • Pain inhibition [ Time Frame: baseline ]
  • Inhibition of pain-related spinal reflex [ Time Frame: baseline ]
  • Inhibition of pain-evoked cortical potentials [ Time Frame: baseline ]
  • Psychological stress [ Time Frame: baseline ]
  • Somatic threat sensitivity [ Time Frame: baseline ]
  • Allostatic load [ Time Frame: baseline ]
  • Environmental structural racism and discrimination [ Time Frame: baseline ]
  • Cultural connectedness [ Time Frame: baseline ]

Central Contacts and Locations

Central contacts

PLAN Lab

918-660-3048tulsa.plan@gmail.com

Jamie L Rhudy, PhD

918-660-3050jamie-rhudy@ouhsc.edu

Locations

University of Oklahoma - Schusterman Center

Recruiting

Tulsa, Oklahoma, United States, 74135

Contacts

PLAN lab

918-660-3048tulsa.plan@gmail.com

Jamie L Rhudy, PhD

918-660-3050jamie-rhudy@ouhsc.edu

More Information

Sponsor

University of Oklahoma

Last update posted

Apr 2, 2025

Last verified

Mar, 2025

Keywords

  • Structural racism and discrimination
  • Stress reactivity
  • Quantitative sensory testing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Oklahoma on 2025-04-02.