Recruiting

Observational Study

Sponsor:

Population Health Research Institute

Code:

NCT05724433

Conditions

Heart Failure

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

Virtual HF Care

Routine HF Care

Study Details

Brief summary:

The clinic visits (intervention) will continue for 90 days, which represents the follow-up period for the primary medication and health status outcomes. The co-primary clinical outcomes will be obtained at 180 days.

Conditions

Heart Failure

Study ID

NCT05724433

Start date

Jan 23, 2023

Status verified date

Mar, 2026

Completion date

Dec 31, 2026

Anticipated

Primary completion date

Sep 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

Adult patients ≥ 18 years old who:

1. Are being discharged after hospitalization or urgent visit for HF as

1. a primary diagnosis or
2. significant complication (prolonging length of stay) of another diagnosis OR Have been referred for an initial consult at a cardiology clinic within 1 week of hospitalization or urgent visit for HF as a primary or secondary diagnosis, as described above.
2. Have left ventricular ejection fraction (LVEF) < 50% within the preceding 3 months.
3. Have NT-proBNP of > 900 pg/ml during hospital admission or within 7 days after discharge from the ED
4. Have a mailing address for patient or caregiver
5. Provide verbal consent

Exclusion Criteria:

1. Died or left hospital before medically advised hospital discharge
2. Unable to self-assess or communicate symptoms (e.g. clinically evident dementia)
3. Unable to engage with digital health technology or follow up
4. Severe valve disease
5. Recipient of or on waiting list for LVAD or cardiac transplant
6. Complex congenital heart disease, hypertrophic obstructive cardiomyopathy, or amyloid cardiomyopathy
7. Severe lung disease with symptoms on minimal exertion, forced expiratory volume during 1 second (FEV1) < 1 litre, severe pulmonary hypertension with RVSP > 60 mm Hg, or on home oxygen
8. Severe kidney disease (persistent eGFR < 30 mL/min/1.73m2)
9. Active malignancy
10. Receiving palliative care or expected life expectancy < 6 months

Study Design

Enrollment

891 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Virtual HF care

Patients will receive virtual HF care to optimize medical therapies

other: Routine HF care

Participants will receive routine HF care

Interventions

Virtual HF Care

Patients will receive virtual visits for 3 months following hospitalization / emergency department (ED) visit for HF. Physiologic measures will be monitored remotely and therapies will be optimized.

Routine HF Care

Care as determined by the treating physician

Primary outcome measure

  • Primary "Hierarchical" Composite Outcome of (Part 1): [ Time Frame: 30 and 90 days ]
  • Primary "Hierarchical" Composite Outcome of (Part 2): [ Time Frame: Time Frame: 30 and 90 Days ]
  • Primary "Hierarchical" Composite Outcome of (Part 3): [ Time Frame: Time Frame: 30 and 90 days. ]
  • Co-primary "Hierarchical" Composite Outcome of: [ Time Frame: 90 and 180 days ]

Central Contacts and Locations

Central contacts

Harriette GC Van Spall, MD MPH

(905) 521-2100Harriette.VanSpall@phri.ca

VICTORY-HF Project office

victory-hf@phri.ca

Locations

St. Joseph's Healthcare Hamilton

Recruiting

Hamilton, Onatrio, Canada, L8N 4A6

Hamilton General Hospital

Recruiting

Hamilton, Ontario, Canada, L8L 2X2

Juravinski Hospital Cancer Centre

Recruiting

Hamilton, Ontario, Canada, L8V 5C2

Unity Health Toronto

Recruiting

Toronto, Ontario, Canada

Contacts

More Information

Sponsor

Population Health Research Institute

Last update posted

Aug 7, 2026

Last verified

Mar, 2026

Keywords

  • Heart Failure
  • Randomized Controlled Trial
  • Digital Health
  • Knowledge Translation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Population Health Research Institute on 2026-08-07.