Recruiting
Phase 1

Cannabis & Opioid

Sponsor:

Shanna Babalonis, PhD

Code:

NCT05729932

Conditions

Opioid Use Disorder

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Interventions

Inhaled vaporized cannabis

Intransal opioid

Study Details

Brief summary:

This study plans to enroll participants with opioid use disorder who are not currently seeking treatment to assess the effects of cannabis on opioid withdrawal and other related outcomes.

Conditions

Opioid Use Disorder

Study ID

NCT05729932

Start date

Sep 10, 2024

Status verified date

Jun, 2026

Completion date

Jun 30, 2027

Anticipated

Primary completion date

Jun 30, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 55

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Current opioid use disorder

Exclusion Criteria:

  • Current medical conditions that require medical management

Study Design

Enrollment

15 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Intranasal Opioid Agonist

Participants will receive non-therapeutic, experimental doses of an opioid agonist or placebo. Active opioid agonist/placebo will be administered once per session and will be administered intransally (snorting).

experimental: Vaporized cannabis

Participants will receive non-therapeutic, experimental doses of active or placebo vaporized cannabis. Active cannabis/placebo will be administered once per session and will be administered via a vaporizer.

Interventions

Inhaled vaporized cannabis

Double-blind cannabis and placebo doses, administered through vaporizer

Intransal opioid

Double-blind opioid and placebo doses, administered intranasal route

Primary outcome measure

  • Change from Baseline - Opioid Withdrawal Severity - Visual Analog Scale (VAS) [ Time Frame: Change from baseline ]

Central Contacts and Locations

Central contacts

Paul Nuzzo, MA

859-323-0002pnuzz2@email.uky.edu

Locations

Center on Drug and Alcohol Research

Recruiting

Lexington, Kentucky, United States, 40508

Contacts

Paul Nuzzo, MA

859-323-0002pnuzz2@email.uky.edu

More Information

Sponsor

Shanna Babalonis, PhD

Last update posted

Jun 18, 2026

Last verified

Jun, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Shanna Babalonis, PhD on 2026-06-18.