Recruiting

Smoking Cessation

Sponsor:

Medical University of South Carolina

Code:

NCT05764759

Conditions

Smoking Cessation

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Smoking cessation e-visit

Treatment as usual

Study Details

Brief summary:

The purpose of this research study is to evaluate an electronic visit (e-visit) for smoking cessation across rural primary care settings. Participants will be randomly assigned to receive either the smoking cessation e-visit or not. The e-visit will look similar to an online questionnaire asking about smoking history, motivation to quit, and preferences for medications for quitting smoking. Participants may receive a prescription for a smoking cessation medication as an outcome of the e-visit, if randomized to the e-visit group, but there is no requirement to take any medication. This study consists of questionnaires and breath samples provided at 4 separate time points throughout the study. Participation in this study will take about 24 weeks.

Conditions

Smoking Cessation

Study ID

NCT05764759

Start date

Mar 7, 2023

Status verified date

Mar, 2026

Completion date

Aug 15, 2027

Anticipated

Primary completion date

Feb 28, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Current cigarette smoking, defined as smoking 1+ cigarettes per day, for 20+ days out of the last 30, for the last 6+ months
  • Age 18+
  • Enrolled in Epic's MyChart program or willing to enroll
  • Possess a valid e-mail address that is checked daily to access study assessments and MyChart messages
  • Owner of an iOS or Android compatible smartphone to provide remote CO readings
  • Have a valid address at which mail can be received (for mailing iCO™)
  • English fluency

Exclusion Criteria:

\- Current engagement in cessation treatment, defined as use of an FDA-approved cessation medication within the last 7 days

Study Design

Enrollment

288 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: Smoking cessation electronic visit (e-visit)

This group will be sent 1) an invitation to complete an electronic visit (e-visit) focused on cigarette smoking and 2) an invitation to complete a follow-up e-visit one-month after the initial e-visit.

active comparator: Treatment as usual (TAU)

This group will be provided information about the state quitline and about the importance of quitting smoking and it will be recommended that they contact their PCP to schedule a medical visit to discuss quitting smoking.

Interventions

Smoking cessation e-visit

electronic visits (e-visits) for smoking cessation

Treatment as usual

Information about the state quitline and about the importance of quitting smoking and a recommendation to contact one's PCP to schedule a medical visit to discuss quitting smoking.

Primary outcome measure

  • Smoking Cessation [ Time Frame: Month 1 ]
  • Smoking Cessation [ Time Frame: Month 3 ]
  • Smoking Cessation [ Time Frame: Month 6 ]
  • Reduction in Cigarettes Per Day [ Time Frame: Month 1 ]
  • Reduction in Cigarettes Per Day [ Time Frame: Month 3 ]
  • Reduction in Cigarettes Per Day [ Time Frame: Month 6 ]

Central Contacts and Locations

Central contacts

Noelle E Natale

843-876-9457natalen@musc.edu

Locations

Medical University of South Carolina

Recruiting

Charleston, South Carolina, United States, 29425

Contacts

Noelle E Natale

843-876-9457natalen@musc.edu

Principal Investigator:

Jennifer Dahne, PhD

More Information

Sponsor

Medical University of South Carolina

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Medical University of South Carolina on 2026-03-05.