Recruiting

MRI

Sponsor:

University of Kansas Medical Center

Code:

NCT05766384

Conditions

Healthy

Eligibility Criteria

Sex: All

Age: 25 - 35

Healthy Volunteers: Not accepted

Interventions

Hyperpolarized Xe129

Study Details

Brief summary:

A subset of young adults participating in the American Lung Association (ALA) Lung Health Cohort (LHC) will be imaged using Hyperpolarized 129Xe MRI to assess lung structure and function. Images will be used to improve the understanding of lung health and early lung abnormalities that may lead to chronic lung disease.

Conditions

Healthy

Study ID

NCT05766384

Start date

Nov 30, 2023

Status verified date

Apr, 2026

Completion date

Mar 31, 2027

Anticipated

Primary completion date

Mar 31, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 25 - 35

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Is enrolled in the American Lung Association Lung Health Cohort Study.
  • Has completed CT imaging for the LHC study within 2 years of the scheduled Xe-MRI date.

Exclusion Criteria:

  • Pacemaker, internal defibrillator or other implanted electronic devices or any standard MRI contraindications (e.g., claustrophobia, > 140 cm shoulder circumference, dependent on weight distribution).
  • Is pregnant or breastfeeding
  • Oxygen saturation (SpO2) <88% on room air or with supplemental oxygen.

Study Design

Enrollment

260 participants

Anticipated

Interventions and Outcome Measures

Interventions

Hyperpolarized Xe129

Inhaled hyperpolarized 129Xe used as a signal agent for MRI of the lungs.

Primary outcome measure

  • Xe-MRI Apparent Diffusion Coefficient [ Time Frame: At baseline imaging timepoint ]

Central Contacts and Locations

Central contacts

Cristal Monge

913-945-9399chernandez@kumc.edu

Locations

University of Iowa

Recruiting

Iowa City, Iowa, United States, 52242

Contacts

Eric Garcia

319-384-8610eric-garcia@uiowa.edu

University of Kansas Medical Center

Recruiting

Kansas City, Kansas, United States, 66160

Contacts

Cristal Monge

913-945-9399chernandez@kumc.edu

Duke University

Recruiting

Durham, North Carolina, United States, 27708

Contacts

Kaitlin Foy

919-479-0861Kaitlin Mae Foy <kaitlin.jones@duke.edu>

More Information

Sponsor

University of Kansas Medical Center

Last update posted

May 1, 2026

Last verified

Apr, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-09. This information was provided to ClinicalTrials.gov by University of Kansas Medical Center on 2026-05-01.