Recruiting

MCED

Sponsor:

Vincere Cancer Center

Code:

NCT05780957

Conditions

Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

MCED

Study Details

Brief summary:

This study is an an observational prospective cohort research study to explore the performance of new blood and urine tests for the early detection of cancer among firefighters.

Conditions

Cancer

Study ID

NCT05780957

Start date

Mar 21, 2023

Status verified date

Nov, 2025

Completion date

Dec 31, 2030

Anticipated

Primary completion date

Dec 31, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18 years of age or older
  • Currently employed as a firefighter, full-time or part-time
  • Taking part in Vincere's First Responder Cancer Screening Program
  • Able to donate blood and urine sample
  • Able to provide informed consent to participate in the study

Exclusion Criteria:

  • Deemed medically unfit for sample donation
  • Personal history of cancer in the last 5 years (with the exception of non-melanoma skin cancer)

Study Design

Enrollment

2000 participants

Anticipated

Interventions and Outcome Measures

Arms

Firefighters who receive multi-cancer early detection (MCED) test

Interventions

MCED

multi-cancer early detection (MCED) test

Primary outcome measure

  • Sensitivity, specificity, positive and negative predictive performance values (PPV and NPV) to detect cancer using Elypta's MCED test, as measured in plasma, in urine, and in plasma and urine combined [ Time Frame: Up to 7 years ]
  • Sensitivity, specificity, positive and negative predictive performance values to detect cancer using Proteotype's MCED test, as measured in plasma. [ Time Frame: Up to 2030 ]

Central Contacts and Locations

Central contacts

Christine Lau, MD

480-306-5390drlau@vincerecancer.com

Locations

Vincere Cancer Center

Recruiting

Scottsdale, Arizona, United States, 85260

Contacts

Christine Lau, MD

(480)306-5390drlau@vincerecancer.com

Principal Investigator:

Vershalee Shukla, MD

More Information

Sponsor

Vincere Cancer Center

Last update posted

Nov 5, 2025

Last verified

Nov, 2025

Keywords

  • Cancer
  • Multi-Cancer Early Detection
  • MCED

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Vincere Cancer Center on 2025-11-05.