Recruiting

Cognitive Function

Sponsor:

Ohio State University

Code:

NCT05795452

Conditions

Psychiatric Problem

Eligibility Criteria

Sex: All

Age: 15 - 23

Healthy Volunteers: Not accepted

Study Details

Brief summary:

This study aims to examine the cognitive and neural pathways underlying the joint impact of chemical and social exposures on two aspects of cognitive function: cognitive control and reward processing. The investigators will use high resolution, multi-band resting state and task functional magnetic resonance imaging (fMRI) as well as neuromelanin stain MRI to identify pathways through which exposure to a mixture of prenatal chemical and early life social exposures alters brain function and behavior. Specifically, the investigators will leverage extant prenatal exposure data (N=550) from the Columbia Center for Children's Environmental Health (CCCEH) Mothers and Newborns (MN) birth cohort and study symptoms and brain function in adolescence.

Conditions

Psychiatric Problem

Study ID

NCT05795452

Start date

Feb 20, 2022

Status verified date

Oct, 2026

Completion date

May, 2027

Anticipated

Primary completion date

May, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 15 - 23

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Participation in either the Mothers and Newborns or Sibling/Hermanos Cohort
  • Available prenatal exposure data leveraged from the CCCEH database
  • Ability of subject or parent to understand and the willingness to sign a written informed consent document.
  • For children, informed assent and parental informed consent to participate in the study
  • Males and females; Age 15-23 years old
  • Adolescents and parents must be English- or Spanish-speaking

Exclusion Criteria:

  • Contraindication for MRI as determined by institutionally approved MRI screening questionnaire

Study Design

Enrollment

250 participants

Anticipated

Interventions and Outcome Measures

Arms

Adolescents from the Mothers and Newborns Cohort

Primary outcome measure

  • Youth Self Report (YSR) from the Child Behavior Checklist (CBCL) [ Time Frame: 15 minutes during study visit ]

Central Contacts and Locations

Central contacts

Amy Margolis, PhD

3472767256amy.margolis@osumc.edu

Locations

Columbia University Irving Medical Center

Recruiting

New York, New York, United States, 10032

Contacts

Julie Herbstman, PhD

jh2678@cumc.columbia.edu

More Information

Sponsor

Ohio State University

Last update posted

Nov 3, 2026

Last verified

Oct, 2026

Keywords

  • Functional magnetic resonance imaging (fMRI)
  • Cognitive function
  • Cognitive Control
  • Reward Processing

Trial information was received from ClinicalTrials.gov and was last updated on 2026-11-04. This information was provided to ClinicalTrials.gov by Ohio State University on 2026-11-03. Recruitment status is synced daily from ClinicalTrials.gov and may not reflect the sponsor's current status. Confirm during your call.