Recruiting

Observational Study

Sponsor:

University Health Network, Toronto

Code:

NCT05796102

Conditions

Esophagogastric Cancer

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Interventions

PET-MRI

Study Details

Brief summary:

This is a single arm, single centre, investigator initiated study to investigate the feasibility of using PET-MRI imaging in radiation treatment workflow in up to 15 patients with esophagogastric cancer. PET-MRI imaging will be completed before the start of radiation treatment. MRI imaging will be completed during radiation treatment and after radiation treatment. These images will not be used to plan the radiation treatment and routine clinical care will be provided.

The goal of this study is to gather information that will allow the radiation team to include MRI and PET imaging into the radiation treatment workflow for patients with esophageal cancer receiving radiation therapy in the future.

Conditions

Esophagogastric Cancer

Study ID

NCT05796102

Start date

Mar 28, 2023

Status verified date

Mar, 2026

Completion date

May, 2027

Anticipated

Primary completion date

May, 2027

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Not accepted

Inclusion Criteria:

  • Patients 18 years or older
  • Diagnosed with locally advanced esophageal cancer being considered for conventional RT >4 weeks
  • Ability and willingness to provide written informed consent

Exclusion Criteria:

  • Contraindication for MRI
  • Contraindication for Gadolinium (i.e. inability to lie supine for at least 60 minutes)
  • Any patient who is pregnant or breastfeeding
  • Pacemaker or implanted defibrillator
  • Claustrophobia

Study Design

Enrollment

15 participants

Anticipated

Intervention Model

Single group

Primary purpose

Health Services Research

Interventions and Outcome Measures

Arms

experimental: PET-MRI

PET-MRI in esophagogastric cancers

Interventions

PET-MRI

A PET/MRI scan is a two-in-one test that combines images from a positron emission tomography (PET) scan and a magnetic resonance imaging (MRI) scan. Magnetic Resonance Imaging (MRI) provides better soft tissue contrast compared to conventional computerized tomography (CT), and when combined with PET, can potentially provide better visualization of the tumor shape, size, and position.

Additional MRI imaging will be completed once during radiation treatment, and once after radiation treatment

Primary outcome measure

  • Feasibility of PET-MRI to visualize and assess impact of RT treatments on esophagogastric tumors [ Time Frame: 2 years ]

Central Contacts and Locations

Central contacts

Rebecca K S Wong, MD

4169462000rebecca.wong@uhn.ca

Locations

Princess Margaret Cancer Centre

Recruiting

Toronto, Ontario, Canada

Contacts

Melissa Bartolo Rego

rmp.regulatory.affairs@rmp.uhn.ca

More Information

Sponsor

University Health Network, Toronto

Last update posted

Mar 5, 2026

Last verified

Mar, 2026

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University Health Network, Toronto on 2026-03-05.