Recruiting

Operant Conditioning

Sponsor:

University of Nevada, Las Vegas

Code:

NCT05801744

Conditions

Stroke

Post-stroke Hemiparesis

Foot Drop

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Interventions

Operant conditioning

Study Details

Brief summary:

The purpose of this study is to examine the changes in reflex pathways in the paretic ankle plantarflexors in individuals with post-stroke hemiparesis using operant conditioning. We are recruiting 5 individuals with chronic post-stroke hemiparesis with foot drop in the affected leg to participate in the reflex training procedure. The study involves 40 visits with a total study duration of about 4 months.

Conditions

Stroke

Post-stroke Hemiparesis

Foot Drop

Study ID

NCT05801744

Start date

Aug 1, 2022

Status verified date

Mar, 2023

Completion date

Dec 31, 2025

Anticipated

Primary completion date

Dec 31, 2025

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • At least 6 months following a single, unilateral stroke, resulting in hemiparesis.
  • Ambulatory with or without assistive device, but must demonstrate a gait deficit which is indicative of foot drop from reduced activation of the tibialis anterior muscle.
  • Able to follow verbal directions.
  • Able to see icons on computer monitor (with or without corrective lenses) from at least 4 feet away.
  • All subjects will be adults at least 18 years old.
  • Know history and current medication management for lower limb spasticity, if any.

Exclusion Criteria:

  • No history of ear disease or balance problems outside of those caused by the stroke.
  • Cerebellar stroke
  • No other neurological disease or injuries other than the stroke affecting the use of the legs and/or walking.

Study Design

Enrollment

5 participants

Anticipated

Intervention Model

Single group

Primary purpose

Treatment

Interventions and Outcome Measures

Arms

experimental: Reciprocal inhibition up conditioning

Each participant completes 6 baseline sessions and 30 up conditioning sessions. In the 30 conditioning sessions, the magnitude of reciprocal inhibition in the paretic leg of participants post-stroke will be up conditioned.

Interventions

Operant conditioning

In this training, individuals with post-stroke hemiparesis are trained to increase the amount of reciprocal inhibition in their paretic leg. By increasing the amount of reciprocal inhibition, the paretic ankle in people post-stroke may exhibit less foot drop.

Primary outcome measure

  • Change in magnitude of reciprocal inhibition [ Time Frame: Before training Baseline, after completion of 30 training sessions, and 1 month after the completion of intervention ]

Central Contacts and Locations

Locations

University of Nevada, Las Vegas

Recruiting

Las Vegas, Nevada, United States, 89154

Contacts

Jing Nong Liang, PT, PhD

702-895-4936jingnong.liang@unlv.edu

Principal Investigator:

Jing Nong Liang, PT, PhD

More Information

Sponsor

University of Nevada, Las Vegas

Last update posted

Apr 6, 2023

Last verified

Mar, 2023

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Nevada, Las Vegas on 2023-04-06.