Recruiting

Exercise Snacks

Sponsor:

University of Toronto

Code:

NCT05810272

Conditions

Inactivity, Physical

Aging

Healthy Aging

Sarcopenia

Muscular Atrophy

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Interventions

Metabolic Trial

15 sit-to-stands with calf raises

Study Details

Brief summary:

The purpose of this study is to assess the impact of 3-days reduced physical activity (<1500 steps/day) with/without 'exercise snacks' (15 chair stands with calf raises every 30 min) on skeletal muscle metabolic health.

Conditions

Inactivity, Physical

Aging

Healthy Aging

Sarcopenia

Muscular Atrophy

Study ID

NCT05810272

Start date

Apr 1, 2023

Status verified date

Jul, 2023

Completion date

Aug 1, 2024

Anticipated

Primary completion date

Mar 1, 2024

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 60 - 70+

Healthy Volunteers: Accepted

Inclusion Criteria:

  • Healthy older (age: 60-80 y) adults
  • BMI between normal to overweight (18.5-29.9 kg/m2)

Exclusion Criteria:

  • Regular use of nonsteroidal anti-inflammatory drugs (with the exception of daily low-dose aspirin)
  • Alcohol consumption during the study period
  • Use of anticoagulants
  • Use of a walker, cane, or assistive walking device
  • Current or recently remised cancer
  • Infectious or gastrointestinal disease
  • Inability to comply with study protocol (e.g., >1,500 steps/day during Step-Reduction Phase)
  • Regular tobacco use
  • Self-reported illicit drug use (e.g. growth hormone, testosterone, etc.)
  • Diagnosed chronic illness (e.g. type 2 diabetes, heart disease, thyroid disease)
  • Hormonal Replacement Therapy

Study Design

Enrollment

20 participants

Anticipated

Allocation

Randomized

Intervention Model

Parallel Assignment

Primary purpose

Other

Interventions and Outcome Measures

Arms

other: Habitual Activity

Following three days of habitual activity, a metabolic trial will be completed wherein participants (10M/10F) will be assessed for their anabolic response to a protein-carbohydrate meal.

experimental: Step-Reduction

Participants will undergo three days of reduced physical activity (<1,500 steps/day) prior to a metabolic trial to establish their anabolic response to a protein-carbohydrate meal.

Interventions

Metabolic Trial

Participants will undergo a metabolic trial to assess for their anabolic response to a protein-carbohydrate meal.

15 sit-to-stands with calf raises

Participants (n=10; 5F/5M) will be randomized to perform 15 sit-to-stands with calf raises every 30 minutes for the 4 hour duration between muscle biopsies

Primary outcome measure

  • Myofibrillar protein synthesis rates [ Time Frame: 5 Hours ]

Central Contacts and Locations

Central contacts

Daniel R Moore, PhD

4169464088dr.moore@utoronto.ca

Matthew J Lees, PhD

matthew.lees@utoronto.ca

Locations

Goldring Center for High Performance Sport

Recruiting

Toronto, Ontario, Canada, M5S 2C9

Contacts

Matthew J Lees, PhD

416-946-0400matthew.lees@utoronto.ca

Hugo JW Fung, PhD (c)

hugojernwai.fung@utoronto.ca

More Information

Sponsor

University of Toronto

Last update posted

Jul 13, 2023

Last verified

Jul, 2023

Keywords

  • Skeletal Muscle
  • Step-Reduction
  • Aging
  • Anabolic Resistance
  • Physical Activity
  • Stable Isotopes

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Toronto on 2023-07-13.