Recruiting

Dairy & AlternativesThe Effect of Dairy and Dairy-Free Alternative Beverages on Post-Exercise Anabolism in Active Youth

Sponsor:

University of Toronto

Code:

NCT05827666

Conditions

Dietary Proteins

Indicator Amino Acid Oxidation

Eligibility Criteria

Sex: All

Age: 8 - 16

Healthy Volunteers: Accepted

Interventions

2% milk beverage

Almond milk alternative beverage

Soy milk alternative beverage

Rice milk alternative beverage

Study Details

Brief summary:

The growth and development of lean body mass (i.e., muscle and bone) is instrumental to health and performance across the lifespan, especially in youth, as they actively experience growth. Thus, it is important to capitalize on physical activity and nutrition (especially dietary protein), to support the accretion of lean tissues. Eating a protein-rich meal or performing physical activity can stimulate protein synthesis, and when repeated over time, lean body mass accretion. There is currently an increasing market demand for non-dairy alternatives, due to multiple reasons including environmental, ethical, or taste preferences. However, it is important to understand how different beverages may support 'growth' (anabolism) of lean tissues after exercise. Research in adults has shown that dairy milk is superior to non-dairy milk beverages for supporting post-exercise recovery and muscle protein synthesis. However, the impact of dairy and non-dairy milk alternatives on recovery from exercise is not well understood in children. By understanding the milk beverage that best supports post-exercise recovery, the investigators can determine the optimal nutritional environment to facilitate the growth of lean tissues in the body.

Conditions

Dietary Proteins

Indicator Amino Acid Oxidation

Study ID

NCT05827666

Start date

Feb 1, 2023

Status verified date

Apr, 2023

Completion date

Dec, 2023

Anticipated

Primary completion date

Dec, 2023

Anticipated

Eligibility Criteria

Sex: All

Age: 8 - 16

Healthy Volunteers: Accepted

Inclusion Criteria:

Between the ages of 8-16 years
Children: >-1 y age from peak height velocity\* (aPHV)
Adolescents: -0.5 to 1.5 aPHV
An age and sex-specific minimum of 75th percentile Beep Test level
Considered healthy based on responses to the PAR-Q+ and a medical history form \*NOTE: age from peak height velocity (aPHV): sitting/standing height

Exclusion Criteria:

Almond or soy allergy
Lactose intolerance
If enrolled as a child participant: biological age outside of >-1 years from aPHV
If enrolled as an adolescent participant: biological age outside -0.5 to 1.5 aPHV
Inability to perform physical activity as determined by the PAR-Q+ and iPAQ
Inability to adhere to protocol guidelines (e.g., 2-day controlled diet)
Diagnosed medical condition under the care of a physician (e.g., type 1 diabetes)
Consuming any medications known to affect protein metabolism (e.g., corticosteroids, non-steroidal anti-inflammatories)
Failure to complete all four metabolic trials within four months

Study Design

Enrollment

24 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Other

Interventions and Outcome Measures

Arms

active comparator: Children

Participants will undergo four metabolic trials in a randomized crossover design, where they will be provided with an isoenergetic (i.e., equal calories) amount of one of the following beverages upon completing a standardized bout of variably intensity exercise: 2% milk, almond 'milk,' soy 'milk,' or rice 'milk.'

active comparator: Adolescent females

active comparator: Adolescent males

Interventions

2% milk beverage

Protein provided at 0.3 g/kg fat-free mass. All other conditions (almond, soy and rice milk alternative beverages) will be matched to the same energy content (i.e., isoenergetic). Macronutrient content of beverage (per 100 g): Calories: 52 kcal; Fat: 2.25 g; Carbohydrates: 4.8 g; Protein: 3.3 g.

Almond milk alternative beverage

Matched to the same energy intake as 0.3 g/kg FFM of 2% milk. Macronutrient content of beverage (per 100 g): Calories: 24 kcal; Fat: 1.13 g; Carbohydrates: 3.1 g; Protein: 0.3 g.

Soy milk alternative beverage

Matched to the same energy intake as 0.3 g/kg FFM of 2% milk. Macronutrient content of beverage (per 100 g): Calories: 39 kcal; Fat: 1.70 g; Carbohydrates: 3.0 g; Protein: 2.9 g.

Rice milk alternative beverage

Matched to the same energy intake as 0.3 g/kg FFM of 2% milk. Macronutrient content of beverage (per 100 g): Calories: 49 kcal; Fat: 1.09 g; Carbohydrates: 9.8 g; Protein: 0.1 g.

Primary outcome measure

F13CO2 [ Time Frame: Duration of the metabolic trial (7 hours) ]

Central Contacts and Locations

Central contacts

Daniel R Moore, PhD

4169464088 dr.moore@utoronto.ca

Hugo JW Fung, PhD (c)

hugojernwai.fung@utoronto.ca

Locations

Goldring Centre for High Performance and Sport

Recruiting

Toronto, Ontario, Canada, M5S 2C9

Contacts

Daniel Moore, PhD

4169464088 dr.moore@utoronto.ca

Nicki Pourhashemi, BSc

6478817899 nicki.pourhashemi@mail.utoronto.ca

More Information

Sponsor

University of Toronto

Last update posted

Apr 25, 2023

Last verified

Apr, 2023

Keywords

Nutrition in Youth
Growth
Active youth
Protein metabolism
Lean body mass
Whole food matrix
Protein beverage
Children
Adolescent
Indicator Amino Acid Oxidation

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by University of Toronto on 2023-04-25.