Recruiting

Physical Activity

Sponsor:

Brigham and Women's Hospital

Code:

NCT05838508

Conditions

Life Style

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Interventions

Exercise intervention

Study Details

Brief summary:

The goal of this study is to understand the interaction between the circadian system and physical activity.

Participants will:

  • complete 2 inpatient stays
  • perform moderate exercise
  • be provided with identical meals
  • have frequent blood draws
  • provide urine and saliva samples

Conditions

Life Style

Study ID

NCT05838508

Start date

Oct 11, 2024

Status verified date

Jun, 2025

Completion date

Aug 30, 2026

Anticipated

Primary completion date

Aug 30, 2026

Anticipated

Eligibility Criteria

Eligibility Criteria

Sex: All

Age: 18 - 45

Healthy Volunteers: Accepted

Inclusion Criteria:

  • 18-45 yr old
  • Body mass index (BMI) 18.5 - 34.9 kg/m2
  • No acute, chronic or debilitating medical conditions (e.g. metabolic, cardiovascular, respiratory, neurological, cancers, etc.)
  • Willing to adhere to the protocol requirements for the duration of the study

Exclusion Criteria:

  • Currently smoking/vaping or 5 or more years of smoking/vaping
  • Currently pregnant or breastfeeding
  • History of drug or alcohol dependency
  • History of psychiatric illness or disorder
  • Any hospitalization due to COVID-19
  • Inability to exercise for any reason
  • Any known contraindication to exercise testing based on current ACSM guidelines

Study Design

Enrollment

26 participants

Anticipated

Allocation

Randomized

Intervention Model

Crossover

Primary purpose

Basic Science

Interventions and Outcome Measures

Arms

experimental: Exercise A-B Intervention

The Exercise A first, then the Exercise B intervention.

experimental: Exercise B-A Intervention

The Exercise B first, then the Exercise A intervention.

Interventions

Exercise intervention

Research participants will be assigned to two exercise conditions.

Primary outcome measure

  • glucose level [ Time Frame: 24-hour test period after exercise ]
  • mean arterial pressure [ Time Frame: 24-hour test period after exercise ]

Central Contacts and Locations

Central contacts

Jingyi Qian, PhD

6175257423jqian@bwh.harvard.edu

Vy Nguyen, B.S.

617-525-0662vnguyen42@bwh.harvard.edu

Locations

Brigham and Women's Hospital

Recruiting

Boston, Massachusetts, United States, 02115

Contacts

Jingyi Qian, PhD

6175257423jqian@bwh.harvard.edu

Vy Nguyen, B.S.

617-525-0662vnguyen42@bwh.harvard.edu

Principal Investigator:

Jingyi Qian, PhD

More Information

Sponsor

Brigham and Women's Hospital

Last update posted

Jun 13, 2025

Last verified

Jun, 2025

Keywords

  • exercise
  • circadian system
  • physical activity
  • glucose tolerance
  • blood pressure

Trial information was received from ClinicalTrials.gov and was last updated on 2026-09-10. This information was provided to ClinicalTrials.gov by Brigham and Women's Hospital on 2025-06-13.